Abstract
Several studies over the last years have demonstrated that statins exhibit actions beyond that of lipid-lowering (pleiotropic effects) ranging from improving endothelial function, modulating the inflammatory response, maintaining plaque stability and preventing thrombus formation. Since the interplay among platelets, cells and other components of atherosclerotic lesions as well as the coagulation system play an important role in the progression of atherosclerosis and in the development of acute coronary syndromes, these non-lipid properties of statins may help to explain the early and significant reduction of cardiovascular events reported in several clinical trials of statin therapy. This review focuses on the experimental and clinical results regarding the antiplatelet/antithrombotic effects of statins.
Keywords: Atherosclerosis, coronary artery disease, platelets, statins, thrombosis, HMG-CoA, lipoprotein (LDL) receptors, pleiotropic effects, prothrombotic, fibrinolytic mechanisms, atherothrombosis, atherosclerotic lesions, acute coronary syndromes, angioplasty, subendothelial collagen, Willebrand factor, 21, GPVI, GPIb-IX, hypercholesterolaemia, normocholesterolaemic, cytosolic calcium, thromboxane A2 (TxA2), dehydro-TxB2 (a major metabolite of TxA2), protein 8, LDL oxLDL, simvastatin, atorvastatin, flu-vastatin, pravastatin, mitogen activated protein kinases (MAP, especially Erk2, nuclear factor kappa B (NF-B), Akt modulation, Atherosclerotic tissues, oxide (NO) syn-thase (NOS) activity, oxLDL, CD36, fibrinopeptide, aspirin, thrombin cleavage peptides, lovastatin therapy, GREACE, HERS, Clopidogrel, cytochrome, P450 (CYP450) isoenzymes, sim-vastatin, lovastatin
Current Pharmaceutical Design
Title: The Antiplatelet and Antithrombotic Actions of Statins
Volume: 16 Issue: 34
Author(s): John V. Mitsios, Athanasios I. Papathanasiou, John A. Goudevenos and Alexandros D. Tselepis
Affiliation:
Keywords: Atherosclerosis, coronary artery disease, platelets, statins, thrombosis, HMG-CoA, lipoprotein (LDL) receptors, pleiotropic effects, prothrombotic, fibrinolytic mechanisms, atherothrombosis, atherosclerotic lesions, acute coronary syndromes, angioplasty, subendothelial collagen, Willebrand factor, 21, GPVI, GPIb-IX, hypercholesterolaemia, normocholesterolaemic, cytosolic calcium, thromboxane A2 (TxA2), dehydro-TxB2 (a major metabolite of TxA2), protein 8, LDL oxLDL, simvastatin, atorvastatin, flu-vastatin, pravastatin, mitogen activated protein kinases (MAP, especially Erk2, nuclear factor kappa B (NF-B), Akt modulation, Atherosclerotic tissues, oxide (NO) syn-thase (NOS) activity, oxLDL, CD36, fibrinopeptide, aspirin, thrombin cleavage peptides, lovastatin therapy, GREACE, HERS, Clopidogrel, cytochrome, P450 (CYP450) isoenzymes, sim-vastatin, lovastatin
Abstract: Several studies over the last years have demonstrated that statins exhibit actions beyond that of lipid-lowering (pleiotropic effects) ranging from improving endothelial function, modulating the inflammatory response, maintaining plaque stability and preventing thrombus formation. Since the interplay among platelets, cells and other components of atherosclerotic lesions as well as the coagulation system play an important role in the progression of atherosclerosis and in the development of acute coronary syndromes, these non-lipid properties of statins may help to explain the early and significant reduction of cardiovascular events reported in several clinical trials of statin therapy. This review focuses on the experimental and clinical results regarding the antiplatelet/antithrombotic effects of statins.
Export Options
About this article
Cite this article as:
V. Mitsios John, I. Papathanasiou Athanasios, A. Goudevenos John and D. Tselepis Alexandros, The Antiplatelet and Antithrombotic Actions of Statins, Current Pharmaceutical Design 2010; 16 (34) . https://dx.doi.org/10.2174/138161210794455120
DOI https://dx.doi.org/10.2174/138161210794455120 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Von Willebrand Factor: Drug and Drug Target
Cardiovascular & Hematological Disorders-Drug Targets Effects of Imidazolic Agonism on Blood Pressure, Sympathetic Activity, Left Ventricular Hypertrophy and Insulin Resistance
Current Hypertension Reviews Lipid Lowering Agents and the Endothelium: An Update after 4 Years
Current Vascular Pharmacology Dietary Patterns in Alzheimers Disease and Cognitive Aging
Current Alzheimer Research Biological Signals Sensing with Wearable Technologies and an ECG Athlete Design
Recent Patents on Biomedical Engineering (Discontinued) Editorial: The Need of Time: Development of New Antimicrobials
Current Topics in Medicinal Chemistry Optimal Antibiotic Therapy in the Management of the Lung of the Critically Ill
Current Respiratory Medicine Reviews Bergamot Juice Extract Inhibits Proliferation by Inducing Apoptosis in Human Colon Cancer Cells
Anti-Cancer Agents in Medicinal Chemistry Induced Pluripotent Stem Cells (iPSCs) Derived from Different Cell Sources and their Potential for Regenerative and Personalized Medicine
Current Molecular Medicine A Multicenter Prospective Hospital-based Cohort Study on the Efficacy and Safety of Pitavastatin
Current Diabetes Reviews The Role of Polyunsaturated Fatty Acids (PUFA) in the Treatment of Dyslipidemias
Current Pharmaceutical Design Discussion on Pharmacogenetic Interaction in G6PD Deficiency and Methods to Identify Potential Hemolytic Drugs
Cardiovascular & Hematological Disorders-Drug Targets Impact of Genetic Polymorphisms and Drug – Drug Interactions on Clopidogrel and Prasugrel Response Variability
Current Drug Metabolism Development of Arene Ruthenium Antitumor Complexes
Mini-Reviews in Medicinal Chemistry Modulation of Neutrophil Function by Hormones
Current Immunology Reviews (Discontinued) ACE Inhibitor Delapril Prevents Ca<sup>2+</sup>-Dependent Blunting of I<sub>K1</sub> and Ventricular Arrhythmia in Ischemic Heart Disease
Current Molecular Medicine Physiological Significance and Therapeutic Potential of Adrenomedullin in Pulmonary Hypertension
Cardiovascular & Hematological Disorders-Drug Targets The Effects of Drugs Used in Anaesthesia on Platelet Membrane Receptors and on Platelet Function
Current Drug Targets Myeloperoxidase as a Target for the Treatment of Inflammatory Syndromes: Mechanisms and Structure Activity Relationships of Inhibitors
Current Medicinal Chemistry Mechanisms of Enhanced Vasoconstriction in the Mouse Model of Atherosclerosis: the Beneficial Effects of Sildenafil
Current Pharmaceutical Biotechnology