Abstract
Objectives: Beta-lactam antibiotics represent the most commonly prescribed antibacterial agents. Since many bacteria have developed resistance to older agents, new beta-lactams have been introduced constantly. In the late 1970s, a new class of exceptionally broad-spectrum beta-lactams, the carbapenems, was identified. The carbapenems, such as the most popular imipenem and meropenem, have the widest spectra of antibacterial activity of all the beta-lactams and provide excellent coverage of many gram-negative and gram-positive aerobic and anaerobic bacteria. Despite the wide antibacterial spectrum, the carbapenems globally lack activity against Enterococcus faecium, methicillin-resistant Staphylococcus aureus (MRSA) and Stenotrophomonas maltophilia. Methods: We reviewed the principal characteristics of the novel carbapenems and their clinical implications. Results and conclusions: We included in our review: ertapenem, biapenem, panipenem, doripenem, tebipenem pivoxil and tomopenem.
Keywords: Carbapenems, imipenem, meropenem, ertapenem, biapenem, panipenem, tebipenem pivoxil, doripenem
Current Medicinal Chemistry
Title: Current Status of Newer Carbapenems
Volume: 16 Issue: 5
Author(s): Matteo Bassetti, Laura Nicolini, Silvano Esposito, Elda Righi and Claudio Viscoli
Affiliation:
Keywords: Carbapenems, imipenem, meropenem, ertapenem, biapenem, panipenem, tebipenem pivoxil, doripenem
Abstract: Objectives: Beta-lactam antibiotics represent the most commonly prescribed antibacterial agents. Since many bacteria have developed resistance to older agents, new beta-lactams have been introduced constantly. In the late 1970s, a new class of exceptionally broad-spectrum beta-lactams, the carbapenems, was identified. The carbapenems, such as the most popular imipenem and meropenem, have the widest spectra of antibacterial activity of all the beta-lactams and provide excellent coverage of many gram-negative and gram-positive aerobic and anaerobic bacteria. Despite the wide antibacterial spectrum, the carbapenems globally lack activity against Enterococcus faecium, methicillin-resistant Staphylococcus aureus (MRSA) and Stenotrophomonas maltophilia. Methods: We reviewed the principal characteristics of the novel carbapenems and their clinical implications. Results and conclusions: We included in our review: ertapenem, biapenem, panipenem, doripenem, tebipenem pivoxil and tomopenem.
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Cite this article as:
Bassetti Matteo, Nicolini Laura, Esposito Silvano, Righi Elda and Viscoli Claudio, Current Status of Newer Carbapenems, Current Medicinal Chemistry 2009; 16 (5) . https://dx.doi.org/10.2174/092986709787458498
DOI https://dx.doi.org/10.2174/092986709787458498 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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