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Current Pharmaceutical Analysis

Editor-in-Chief

ISSN (Print): 1573-4129
ISSN (Online): 1875-676X

Evaluation of Pirkle Stationary Phases in Chiral Method Development Screening for Compounds of Pharmaceutical Interest

Author(s): William B. Holzheuer, Megan M. Wong and Gregory K. Webster

Volume 5, Issue 1, 2009

Page: [10 - 20] Pages: 11

DOI: 10.2174/157341209787314918

Price: $65

Abstract

The majority of enantiomeric separations for purity analysis and quality control continue to be performed by normal phase liquid chromatography (LC) and supercritical fluid chromatography (SFC). For much of the pharmaceutical industry, chiral method development relies heavily on column screening activities. Much work has been performed looking at polysaccharide based stationary phases (Diacel AD, OD, AS, and OJ); however, analytical laboratories must be ready to continually address the changing nature of molecules being developed in the pharmaceutical industry. For this reason, a comparison of commercially available Pirkle stationary phases to compliment polysaccharide column screens was studied. Using normal phase LC and SFC, several Pirkle stationary phases were used to screen a study library of pharmaceutically relevant compounds. The results of this investigation are reported.

Keywords: Chiral screening, Pirkle chiral stationary phases, Liquid chromatography, Supercritical fluid chromatography


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