Abstract
Hyphenation with liquid chromatography has become indispensable in mass spectrometry-based proteomics. Sample complexity together with the large variations in dynamic range can be only tackled using techniques that isolate and/or concentrate individual components prior to mass spectrometric analysis. In this review the most recent developments in micro/nanoliquid chromatography interfaced with MALDI and electrospray ionisation are discussed. Particular attention is focused on all applications related to quantitative proteomics.
Keywords: Liquid Chromatography, Mass Spectrometry, proteomics, MALDI, electrospray ionisation
Combinatorial Chemistry & High Throughput Screening
Title: Offline and Online Liquid Chromatography Mass Spectrometry in Quantitative Proteomics
Volume: 12 Issue: 2
Author(s): Jessica Z. Bereszczak and Francesco L. Brancia
Affiliation:
Keywords: Liquid Chromatography, Mass Spectrometry, proteomics, MALDI, electrospray ionisation
Abstract: Hyphenation with liquid chromatography has become indispensable in mass spectrometry-based proteomics. Sample complexity together with the large variations in dynamic range can be only tackled using techniques that isolate and/or concentrate individual components prior to mass spectrometric analysis. In this review the most recent developments in micro/nanoliquid chromatography interfaced with MALDI and electrospray ionisation are discussed. Particular attention is focused on all applications related to quantitative proteomics.
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Cite this article as:
Bereszczak Z. Jessica and Brancia L. Francesco, Offline and Online Liquid Chromatography Mass Spectrometry in Quantitative Proteomics, Combinatorial Chemistry & High Throughput Screening 2009; 12 (2) . https://dx.doi.org/10.2174/138620709787315418
DOI https://dx.doi.org/10.2174/138620709787315418 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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