Abstract
Fenofibrate represents the most commonly used fibric acid derivative. The drug exerts its metabolic effects by modulating the expression of several genes involved in lipoprotein metabolism. In addition, numerous studies suggest that fenofibrate may also affect the progression of the atherosclerotic process by several lipid-independent mechanisms. This review considers the clinical pharmacology of fenofibrate and the current evidence on the pleiotropic effects of this fibric acid derivative.
Keywords: Fenofibrate, pleiotropic effects, inflammation, endothelial function, oxidative stress, lipoprotein-associated enzymes, cardiac remodeling, angiogenesis
Current Pharmaceutical Design
Title: Pleiotropic Effects of Fenofibrate
Volume: 15 Issue: 5
Author(s): V. Tsimihodimos, E. Liberopoulos and M. Elisaf
Affiliation:
Keywords: Fenofibrate, pleiotropic effects, inflammation, endothelial function, oxidative stress, lipoprotein-associated enzymes, cardiac remodeling, angiogenesis
Abstract: Fenofibrate represents the most commonly used fibric acid derivative. The drug exerts its metabolic effects by modulating the expression of several genes involved in lipoprotein metabolism. In addition, numerous studies suggest that fenofibrate may also affect the progression of the atherosclerotic process by several lipid-independent mechanisms. This review considers the clinical pharmacology of fenofibrate and the current evidence on the pleiotropic effects of this fibric acid derivative.
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Cite this article as:
Tsimihodimos V., Liberopoulos E. and Elisaf M., Pleiotropic Effects of Fenofibrate, Current Pharmaceutical Design 2009; 15 (5) . https://dx.doi.org/10.2174/138161209787315675
DOI https://dx.doi.org/10.2174/138161209787315675 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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