Abstract
Increasing evidence shows that the interaction between neoplastic cells and the surrounding stroma is a critical factor in solid tumor growth. The tumor stroma is made up of diverse cellular populations including macrophages, lymphocytes, vascular cells, and carcinoma-associated fibroblasts. The complex interactions between the stroma and neoplastic cells are largely unexplored. Initial therapies aimed at disrupting angiogenesis within the tumor microenvironment have met with success in a number of tumor types. An improved understanding of stromal signaling pathways is likely to identify additional novel therapeutic targets.
Keywords: Tumor Stroma, Cancer Therapy, neoplastic cells, lymphocytes, vascular cells, angiogenesis
Current Pharmaceutical Biotechnology
Title: Targeting the Tumor Stroma in Cancer Therapy
Volume: 10 Issue: 2
Author(s): Kevin Anton and John Glod
Affiliation:
Keywords: Tumor Stroma, Cancer Therapy, neoplastic cells, lymphocytes, vascular cells, angiogenesis
Abstract: Increasing evidence shows that the interaction between neoplastic cells and the surrounding stroma is a critical factor in solid tumor growth. The tumor stroma is made up of diverse cellular populations including macrophages, lymphocytes, vascular cells, and carcinoma-associated fibroblasts. The complex interactions between the stroma and neoplastic cells are largely unexplored. Initial therapies aimed at disrupting angiogenesis within the tumor microenvironment have met with success in a number of tumor types. An improved understanding of stromal signaling pathways is likely to identify additional novel therapeutic targets.
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Cite this article as:
Anton Kevin and Glod John, Targeting the Tumor Stroma in Cancer Therapy, Current Pharmaceutical Biotechnology 2009; 10 (2) . https://dx.doi.org/10.2174/138920109787315088
DOI https://dx.doi.org/10.2174/138920109787315088 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
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