Abstract
Avoiding volatile and toxic organic solvents during each particular phase of synthetic protocols should become important goal of chemical synthesis designers in academia and particularly in the industrial research community. Solvent- free reaction conditions (SFRC) are becoming a widely used experimental technique for the selective and efficient introduction of halogen atoms into organic compounds. The different approaches to the preparation of halosubstituted organic molecules using equimolar amount of the substrate and reagent under SFRC are reviewed and evaluated. Fluorination of various types of organic compounds under SFRC using fluorine gas, N-F reagents, and hydrogen or metal fluorides is compiled. Chloro-, bromo- or iodofunctionalisation under SFRC using molecular halogens, N-halosuccinimides, hydrogen or others halides is reviewed. Oxidative halogenations of comprehensive types of organic compounds under SFRC are evaluated.
Keywords: Solvent- free reaction conditions (SFRC), halogen atoms, organic compounds, Fluorination, N-halosuccinimides
Current Organic Chemistry
Title: Introduction of Halogen Atoms into Organic Compounds Under Solvent- Free Reaction Conditions
Volume: 13 Issue: 1
Author(s): Igor Pravst, Marko Zupan and Stojan Stavber
Affiliation:
Keywords: Solvent- free reaction conditions (SFRC), halogen atoms, organic compounds, Fluorination, N-halosuccinimides
Abstract: Avoiding volatile and toxic organic solvents during each particular phase of synthetic protocols should become important goal of chemical synthesis designers in academia and particularly in the industrial research community. Solvent- free reaction conditions (SFRC) are becoming a widely used experimental technique for the selective and efficient introduction of halogen atoms into organic compounds. The different approaches to the preparation of halosubstituted organic molecules using equimolar amount of the substrate and reagent under SFRC are reviewed and evaluated. Fluorination of various types of organic compounds under SFRC using fluorine gas, N-F reagents, and hydrogen or metal fluorides is compiled. Chloro-, bromo- or iodofunctionalisation under SFRC using molecular halogens, N-halosuccinimides, hydrogen or others halides is reviewed. Oxidative halogenations of comprehensive types of organic compounds under SFRC are evaluated.
Export Options
About this article
Cite this article as:
Pravst Igor, Zupan Marko and Stavber Stojan, Introduction of Halogen Atoms into Organic Compounds Under Solvent- Free Reaction Conditions, Current Organic Chemistry 2009; 13 (1) . https://dx.doi.org/10.2174/138527209787193819
DOI https://dx.doi.org/10.2174/138527209787193819 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements