Abstract
The isolation and structural determination of Martinella alkaloids were first reported in 1995, and since that time these heterocycles have elicited considerable interest from the synthetic community. Although in many respects, these molecules appear to be relatively simple targets, possessing only three stereocenters, an impressive collection of strategies towards the synthesis of these molecules has emerged. This review is a comprehensive overview of both the synthetic approaches to the pyrrolo[3,2-c]quinoline core found in these molecules, as well as a description of the racemic and enantioselective total syntheses reported to date.
Keywords: Martinella alkaloids, synthesis, stereocenters, Radical Cyclizations, Hetero Diels-Alder Approach, (RACE), Snider Approach
Current Organic Chemistry
Title: Synthetic Studies Toward the Martinella Alkaloids
Volume: 12 Issue: 17
Author(s): Carl J. Lovely and Vivek Bararinarayana
Affiliation:
Keywords: Martinella alkaloids, synthesis, stereocenters, Radical Cyclizations, Hetero Diels-Alder Approach, (RACE), Snider Approach
Abstract: The isolation and structural determination of Martinella alkaloids were first reported in 1995, and since that time these heterocycles have elicited considerable interest from the synthetic community. Although in many respects, these molecules appear to be relatively simple targets, possessing only three stereocenters, an impressive collection of strategies towards the synthesis of these molecules has emerged. This review is a comprehensive overview of both the synthetic approaches to the pyrrolo[3,2-c]quinoline core found in these molecules, as well as a description of the racemic and enantioselective total syntheses reported to date.
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Cite this article as:
Lovely J. Carl and Bararinarayana Vivek, Synthetic Studies Toward the Martinella Alkaloids, Current Organic Chemistry 2008; 12 (17) . https://dx.doi.org/10.2174/138527208786241493
DOI https://dx.doi.org/10.2174/138527208786241493 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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