Abstract
The sense of touch is one of the most vital; still, it is incompletely understood. We review the afferent function that allows for the relay of sensory information from the periphery (the skin) to the central nervous system. Within this afferent function, we examine the different integrating levels including several candidates for cutaneous transducers, the conduction of the information via the afferent nervous fibres and the transmission of the sensory stimuli to higher brain structures, resulting in the perception of the different senses. We then examine the efferent system that stimulates the skin by secreting neurotransmitters. Finally, we discuss the tools available to study the cutaneous neurovascular interaction and conclude on a novel test that assesses this interaction triggered by the application of a local non noxious pressure (tactile stimulation).
Keywords: Skin, sensory fibres, microcirculation, touch, receptors, ion channels, mechanosensitivity
Cardiovascular & Hematological Agents in Medicinal Chemistry
Title: Cutaneous Neurovascular Interaction Involved in Tactile Sensation
Volume: 6 Issue: 4
Author(s): B. Fromy, D. Sigaudo-Roussel and J. L. Saumet
Affiliation:
Keywords: Skin, sensory fibres, microcirculation, touch, receptors, ion channels, mechanosensitivity
Abstract: The sense of touch is one of the most vital; still, it is incompletely understood. We review the afferent function that allows for the relay of sensory information from the periphery (the skin) to the central nervous system. Within this afferent function, we examine the different integrating levels including several candidates for cutaneous transducers, the conduction of the information via the afferent nervous fibres and the transmission of the sensory stimuli to higher brain structures, resulting in the perception of the different senses. We then examine the efferent system that stimulates the skin by secreting neurotransmitters. Finally, we discuss the tools available to study the cutaneous neurovascular interaction and conclude on a novel test that assesses this interaction triggered by the application of a local non noxious pressure (tactile stimulation).
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Fromy B., Sigaudo-Roussel D. and Saumet L. J., Cutaneous Neurovascular Interaction Involved in Tactile Sensation, Cardiovascular & Hematological Agents in Medicinal Chemistry 2008; 6 (4) . https://dx.doi.org/10.2174/187152508785909438
DOI https://dx.doi.org/10.2174/187152508785909438 |
Print ISSN 1871-5257 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6182 |
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