Aurora B Kinase and Passenger Proteins as Targets for Cancer Therapy

Thi   My   Nhung Hoang; Marlene      Delacour-Larose; Annie      Molla

Abstract

The chromosome passenger complex (CPC) is composed of five proteins: Aurora B kinase, Borealin, INCENP, Survivin and TD-60. CPC functions as an oligo-enzyme, each member activating the catalytic subunit, Aurora B kinase. CPC controls chromosome congression, bidirectional tension on kinetochores and spindle checkpoint signalling as well as cytokinesis completion. CPC is thus a key regulator during mitosis; CPC proteins are exclusively expressed during mitosis and are up-regulated in many tumours. Their overexpression correlates with the level of genomic instability within tumours. Altogether, this leads to the proposal of passenger proteins as potential targets for cancer therapy. This review describes the chromosomal passenger complex and its involvement in mitosis and the different strategies developed towards its inactivation.

Keywords: Aurora kinase, survivin, borealin, INCENP, passenger proteins, cancer therapy, mitosis, kinase inhibitors, chromosome passenger complex