Abstract
Peptide microarrays have become increasingly accessible in recent years and as a result, more widely applied. Beyond its initial utility in substrate profiling, researchers are adopting peptide microarrays for the comparative screening of many different classes of enzymes, proteins/ proteomes and even living cells. Understanding the basis of peptide interactions at these diverse levels provides an unprecedented window into dissecting the complex cellular circuitries and molecular architectures of living systems. The peptides on the arrays may serve to sense protein activity (like substrates) or act as small molecule ligands (for potential therapeutic leads) in profiling, detection or diagnostic applications. This review will chart the progress made in peptide microarrays, with a focus on the recent advances that could impact how the field will be shaped in the coming years. These developments, along with the diminishing costs of library synthesis and growing commercial support, recognize that peptide microarrays will no longer remain just a vital research tool, but also a platform that could now be harnessed for wider drug discovery and point-of-care applications.
Keywords: Microarray, peptides, high-throughput screening, combinatorial chemistry, chemical biology, proteomics, affinity profiling, protein fingerprinting
Current Pharmaceutical Design
Title: Peptide Microarrays: Next Generation Biochips for Detection, Diagnostics and High-Throughput Screening
Volume: 14 Issue: 24
Author(s): Mahesh Uttamchandani and Shao Q. Yao
Affiliation:
Keywords: Microarray, peptides, high-throughput screening, combinatorial chemistry, chemical biology, proteomics, affinity profiling, protein fingerprinting
Abstract: Peptide microarrays have become increasingly accessible in recent years and as a result, more widely applied. Beyond its initial utility in substrate profiling, researchers are adopting peptide microarrays for the comparative screening of many different classes of enzymes, proteins/ proteomes and even living cells. Understanding the basis of peptide interactions at these diverse levels provides an unprecedented window into dissecting the complex cellular circuitries and molecular architectures of living systems. The peptides on the arrays may serve to sense protein activity (like substrates) or act as small molecule ligands (for potential therapeutic leads) in profiling, detection or diagnostic applications. This review will chart the progress made in peptide microarrays, with a focus on the recent advances that could impact how the field will be shaped in the coming years. These developments, along with the diminishing costs of library synthesis and growing commercial support, recognize that peptide microarrays will no longer remain just a vital research tool, but also a platform that could now be harnessed for wider drug discovery and point-of-care applications.
Export Options
About this article
Cite this article as:
Uttamchandani Mahesh and Yao Q. Shao, Peptide Microarrays: Next Generation Biochips for Detection, Diagnostics and High-Throughput Screening, Current Pharmaceutical Design 2008; 14 (24) . https://dx.doi.org/10.2174/138161208785777450
DOI https://dx.doi.org/10.2174/138161208785777450 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Microfluidic Hydrodynamic Cell Separation: A Review
Micro and Nanosystems Opioids and the Blood-Brain Barrier: A Dynamic Interaction with Consequences on Drug Disposition in Brain
Current Neuropharmacology Chemical Characterization and Antioxidant Potential of <i>Athroisma proteiformis</i> Essential Oil
The Natural Products Journal Oleanolic Acid and Related Triterpenoids from Olives on Vascular Function: Molecular Mechanisms and Therapeutic Perspectives
Current Medicinal Chemistry Mapping Protein: Carbohydrate Interactions
Current Protein & Peptide Science Techniques of Structural Characterization of Dendrimers
Current Organic Chemistry L-Valine and L-Proline - Solid-State IR-LD Spectroscopic Study
Protein & Peptide Letters Amendatory Effect of Flavonoids in Alzheimer's Disease Against Mitochondrial Dysfunction
Current Drug Targets Functional and Structural Characterization of Helicobacter pylori ClpX: A Molecular Chaperone of Hsp100 Family
Protein & Peptide Letters On Therapeutic Drug Monitoring of Thiopurines in Inflammatory Bowel Disease; Pharmacology, Pharmacogenomics, Drug Intolerance and Clinical Relevance
Current Drug Metabolism The Screening of Renoprotective Agents by 99mTc-DMSA: A Review of Preclinical Studies
Current Radiopharmaceuticals Scaling Down SAGE: from miniSAGE to microSAGE
Current Pharmaceutical Biotechnology Drug Metabolism and Pharmacokinetics of Dammarane Triterpenoids
Current Drug Metabolism Hyaluronic Acid: The Reason for Its Variety of Physiological and Biochemical Functional Properties
Applied Clinical Research, Clinical Trials and Regulatory Affairs Solvent-Free and Self-Catalyzed Three-Component Synthesis of Diversely Substituted Pyrazolo[1,4]thiazepinones of Potential Antitumor Activity
Current Organic Synthesis Synthetic Aziridines in Medicinal Chemistry: A Mini-Review
Mini-Reviews in Medicinal Chemistry Molecular Mechanism of Anti-tumor Effect by Triptolide in Hematological Malignancies
Current Signal Transduction Therapy New Developments in Targeted Analysis of Protein Posttranslational Modifications
Current Proteomics A Comparative Study of Selected Drug Delivery Systems: Key Emphasis on Cocrystallization
Drug Delivery Letters The Antiviral and Antimalarial Drug Repurposing in Quest of Chemotherapeutics to Combat COVID-19 Utilizing Structure-Based Molecular Docking
Combinatorial Chemistry & High Throughput Screening