Abstract
Leishmaniasis is a parasitic infection that affects millions of people worldwide, especially in tropical and subtropical areas, and is responsible for high mortality and morbidity. The therapies available up to the present are far from satisfactory and, since leishmaniasis affects poor people in poor regions, the development of new drugs has been neglected due to the lack of commercial motivation. Safe and orally available drugs, especially against the visceral form of the disease, are needed. An overview of the main strategies for antileishmanial drug development, mainly focused on the target-based drug development approach, is given.
Keywords: Leishmania, drugs, targets
Current Drug Therapy
Title: Therapy and Further Development of Anti-Leishmanial Drugs
Volume: 3 Issue: 3
Author(s): Joana A. Pinto da Costa Tavares, Ali Ouaissi and Anabela Cordeiro-da-Silva
Affiliation:
Keywords: Leishmania, drugs, targets
Abstract: Leishmaniasis is a parasitic infection that affects millions of people worldwide, especially in tropical and subtropical areas, and is responsible for high mortality and morbidity. The therapies available up to the present are far from satisfactory and, since leishmaniasis affects poor people in poor regions, the development of new drugs has been neglected due to the lack of commercial motivation. Safe and orally available drugs, especially against the visceral form of the disease, are needed. An overview of the main strategies for antileishmanial drug development, mainly focused on the target-based drug development approach, is given.
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Cite this article as:
Pinto da Costa Tavares A. Joana, Ouaissi Ali and Cordeiro-da-Silva Anabela, Therapy and Further Development of Anti-Leishmanial Drugs, Current Drug Therapy 2008; 3 (3) . https://dx.doi.org/10.2174/157488508785747871
DOI https://dx.doi.org/10.2174/157488508785747871 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
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