Abstract
Integrins have been reported to mediate cell survival, proliferation, differentiation, and migration programs. For this reason, the past few years have seen an increased interest in the implications of integrin receptors in atherosclerosis. This review considers the potential role of integrins in atherosclerosis and also addresses why integrins present attractive targets for drug design. It discusses the properties of the integrin-based chemotherapeutic agents currently under consideration clinically and endeavours to provide insights into development of cardiovascular drugs using integrins as targets.
Keywords: Integrin, Cell Adhesion, Atherosclerosis, proliferation, drug design, chemotherapeutic agents, cardiovascular drugs
Current Pharmaceutical Design
Title: The Role of Integrin-Mediated Cell Adhesion in Atherosclerosis: Pathophysiology and Clinical Opportunities
Volume: 14 Issue: 22
Author(s): X. Lu, D. Lu, M. F. Scully and V. V. Kakkar
Affiliation:
Keywords: Integrin, Cell Adhesion, Atherosclerosis, proliferation, drug design, chemotherapeutic agents, cardiovascular drugs
Abstract: Integrins have been reported to mediate cell survival, proliferation, differentiation, and migration programs. For this reason, the past few years have seen an increased interest in the implications of integrin receptors in atherosclerosis. This review considers the potential role of integrins in atherosclerosis and also addresses why integrins present attractive targets for drug design. It discusses the properties of the integrin-based chemotherapeutic agents currently under consideration clinically and endeavours to provide insights into development of cardiovascular drugs using integrins as targets.
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Cite this article as:
Lu X., Lu D., Scully F. M. and Kakkar V. V., The Role of Integrin-Mediated Cell Adhesion in Atherosclerosis: Pathophysiology and Clinical Opportunities, Current Pharmaceutical Design 2008; 14 (22) . https://dx.doi.org/10.2174/138161208785740199
DOI https://dx.doi.org/10.2174/138161208785740199 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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