Current Molecular Pharmacology

In-vitro Pre-Treatment of Cancer Cells with TGF-β1: A Novel Approach of Tail Vein Lung Cancer Metastasis Mouse Model for Anti-Metastatic Studies

Volume: 12   Issue: 4
Pp: 249-260
Ghulam Jilany Khan*, Li Sun, Muhammad Abbas, Muhammad Naveed, Talha Jamshaid, Mirza Muhammad Faran Ashraf Baig and Shengtao Yuan*
DOI: 10.2174/1874467212666190306165703

Mesalazine Activates Adenosine Monophosphate-activated Protein Kinase: Implication in the Anti-inflammatory Activity of this Anti-colitic Drug

Volume: 12   Issue: 4
Pp: 272-280
Heejung Park, Wooseong Kim, Dayoon Kim, Seongkeun Jeong and Yunjin Jung*
DOI: 10.2174/1874467212666190308103448

Bafilomycin-A1 and ML9 Exert Different Lysosomal Actions to Induce Cell Death

Volume: 12   Issue: 4
Pp: 261-271
Soni Shaikh*, Suman K Nandy, Carles Cantí and Sergio Lavandero
DOI: 10.2174/1874467212666190308131250

Synergistic Effect of Epigenetic Inhibitors Decitabine and Suberoylanilide Hydroxamic Acid on Colorectal Cancer In vitro

Volume: 12   Issue: 4
Pp: 281-300
Sonia Abou Najem, Ghada Khawaja, Mohammad Hassan Hodroj and Sandra Rizk*
DOI: 10.2174/1874467212666190313154531

The Psychiatric Drug Lithium Increases DNA Damage and Decreases Cell Survival in MCF-7 and MDA-MB-231 Breast Cancer Cell Lines Expos ed to Ionizing Radiation

Volume: 12   Issue: 4
Pp: 301-310
Maryam Rouhani*, Samira Ramshini and Maryam Omidi
DOI: 10.2174/1874467212666190503151753

Effects of Myo-inositol Alone and in Combination with Seleno-Lmethionine on Cadmium-Induced Testicular Damage in Mice

Volume: 12   Issue: 4
Pp: 311-323
Salvatore Benvenga, Antonio Micali*, Giovanni Pallio, Roberto Vita, Consuelo Malta, Domenico Puzzolo, Natasha Irrera, Francesco Squadrito, Domenica Altavilla and Letteria Minutoli
DOI: 10.2174/1874467212666190620143303

H19/miR-675-5p Targeting SFN Enhances the Invasion and Metastasis of Nasalpharyngeal Cancer Cells

Volume: 12   Issue: 4
Pp: 324-333
Ting Zhang, Fanghong Lei, Tao Jiang, Lisha Xie, Pin Huang, Pei Li, Yun Huang, Xia Tang, Jie Gong, Yunpeng Lin, Ailan Cheng* and Weiguo Huang*
DOI: 10.2174/1874467212666190719120446

Acknowledgements to Reviewers promotion: free to download

Volume: 12   Issue: 4
Pp: 334-334

DOI: 10.2174/187446721204190920121005

Pharmacokinetic and Pharmacodynamic Aspects of Peyote and Mescaline: Clinical and Forensic Repercussions open access plus

Volume: 12   Issue: 3
Pp: 184-194
Ricardo Jorge Dinis-Oliveira*, Carolina Lança Pereira and Diana Dias da Silva
DOI: 10.2174/1874467211666181010154139

Mitochondria-Targeted Drugs open access plus

Volume: 12   Issue: 3
Pp: 202-214
Roman A. Zinovkin* and Andrey A. Zamyatnin*
DOI: 10.2174/1874467212666181127151059

A Contemporary Overview of PPARα/γ Dual Agonists for the Management of Diabetic Dyslipidemia open access plus

Volume: 12   Issue: 3
Pp: 195-201
Pitchai Balakumar*, Nanjaian Mahadevan and Ramanathan Sambathkumar
DOI: 10.2174/1874467212666190111165015

New Insights in Cannabinoid Receptor Structure and Signaling open access plus

Volume: 12   Issue: 3
Pp: 239-248
Lingyan Ye, Zheng Cao, Weiwei Wang and Naiming Zhou*
DOI: 10.2174/1874467212666190215112036

Targeting Chromatin Remodeling for Cancer Therapy open access plus

Volume: 12   Issue: 3
Pp: 215-229
Jasmine Kaur, Abdelkader Daoud and Scott T. Eblen*
DOI: 10.2174/1874467212666190215112915

Convergence of Canonical and Non-Canonical Wnt Signal: Differential Kat3 Coactivator Usage promotion: free to download

Volume: 12   Issue: 3
Pp: 167-183
Keane K.Y. Lai*, Cu Nguyen, Kyung-Soon Lee, Albert Lee, David P. Lin, Jia-Ling Teo and Michael Kahn*
DOI: 10.2174/1874467212666190304121131

The Endocrine Disruptor Bisphenol A (BPA) Exerts a Wide Range of Effects in Carcinogenesis and Response to Therapy open access plus

Volume: 12   Issue: 3
Pp: 230-238
Shirin A. Hafezi and Wael M. Abdel-Rahman*
DOI: 10.2174/1874467212666190306164507

Does the Development of Vaccines Advance Solutions for Tuberculosis?

Volume: 12   Issue: 2
Pp: 83-104
Manaf AlMatar*, Essam A. Makky, Husam AlMandeal, Emel Eker, Begüm Kayar, Işıl Var and Fatih Köksal
DOI: 10.2174/1874467212666181126151948

MiR-597 Targeting 14-3-3σ Enhances Cellular Invasion and EMT in Nasopharyngeal Carcinoma Cells

Volume: 12   Issue: 2
Pp: 105-114
Lisha Xie, Tao Jiang, Ailan Cheng, Ting Zhang, Pin Huang, Pei Li, Gebo Wen, Fanghong Lei, Yun Huang, Xia Tang, Jie Gong, Yunpeng Lin, Jianke Kuai* and Weiguo Huang*
DOI: 10.2174/1874467212666181218113930

Therapeutic Potential of Morin in Ovalbumin-induced Allergic Asthma Via Modulation of SUMF2/IL-13 and BLT2/NF-kB Signaling Pathway

Volume: 12   Issue: 2
Pp: 122-138
Amit D. Kandhare, Zihao Liu, Anwesha A. Mukherjee and Subhash L. Bodhankar*
DOI: 10.2174/1874467212666190102105052

Mephedrone Impact on Matrix Metalloproteinases Activity - Do they Influence the Memory Processes?

Volume: 12   Issue: 2
Pp: 115-121
Anna Boguszewska-Czubara*, Jacek Kurzepa, Grażyna Biała, Katarzyna Kaszubska, Karolina Grot, Piotr Tarkowski, Joanna Kowalczyk, Serena Silvestro, Caterina Faggio and Barbara Budzyńska
DOI: 10.2174/1874467212666190114154307

Alterations of RNA Metabolism by Proteomic Analysis of Breast Cancer Cells Exposed to Marycin: A New Optically Active Porphyrin

Volume: 12   Issue: 2
Pp: 147-159
Elena Taverna, Maida De Bortoli, Elisa Maffioli, Cristina Corno, Emilio Ciusani, Silvio Trivulzio, Arnaldo Pinelli, Gabriella Tedeschi, Paola Perego and Italia Bongarzone*
DOI: 10.2174/1874467212666190204102112

Activation of GLP-1 and Glucagon Receptors Regulates Bile Homeostasis Independent of Thyroid Hormone

Volume: 12   Issue: 2
Pp: 139-146
Vishal J. Patel, Amit A. Joharapurkar*, Samadhan G. Kshirsagar, Brijesh K. Sutariya, Maulik S. Patel, Rajesh H. Bahekar and Mukul R. Jain
DOI: 10.2174/1874467212666190212112402

Assessment of Genotoxicity of Levosimendan in Human Cultured Lymphocytes

Volume: 12   Issue: 2
Pp: 160-165
Abeer M. Rababa'h*, Omar F. Khabour, Karem H. Alzoubi, Dua'a Al-momani and Mera Ababneh
DOI: 10.2174/1874467212666190306164926

Mechanisms for Radioprotection by Melatonin; Can it be Used as a Radiation Countermeasure?

Volume: 12   Issue: 1
Pp: 2-11
Peyman Amini, Hanifeh Mirtavoos-Mahyari, Elahe Motevaseli, Dheyauldeen Shabeeb, Ahmed Eleojo Musa, Mohsen Cheki, Bagher Farhood, Rasoul Yahyapour, Alireza Shirazi, Nouraddin Abdi Goushbolagh and Masoud Najafi*
DOI: 10.2174/1874467211666180802164449

NADPH Oxidase as a Target for Modulation of Radiation Response; Implications to Carcinogenesis and Radiotherapy

Volume: 12   Issue: 1
Pp: 50-60
Keywan Mortezaee, Nasser Hashemi Goradel, Peyman Amini, Dheyauldeen Shabeeb, Ahmed Eleojo Musa, Masoud Najafi* and Bagher Farhood*
DOI: 10.2174/1874467211666181010154709

Combination Treatment of p53-Null HL-60 cells with Histone Deacetylase Inhibitors and Chlorambucil Augments Apoptosis and Increases BCL6 and p21 Gene Expression

Volume: 12   Issue: 1
Pp: 72-81
Faith A.A. Kwa*, Merrole F. Cole-Sinclair and Miroslav K. Kapuscinski
DOI: 10.2174/1874467211666181010161836

Curcuminoids and Novel Opportunities for the Treatment of Alzheimer's Disease: Which Molecules are Actually Effective?

Volume: 12   Issue: 1
Pp: 12-26
Alexander V. Zholos*, Olesia F. Moroz and Maksim V. Storozhuk*
DOI: 10.2174/1874467211666181012150847

Kinase Targets for Mycolic Acid Biosynthesis in Mycobacterium tuberculosis

Volume: 12   Issue: 1
Pp: 27-49
Shahinda S.R. Alsayed, Chau C. Beh, Neil R. Foster, Alan D. Payne, Yu Yu and Hendra Gunosewoyo*
DOI: 10.2174/1874467211666181025141114

Histone Acetylation Regulates Natriuretic Peptides and Neprilysin Gene Expressions in Diabetic Cardiomyopathy and Nephropathy

Volume: 12   Issue: 1
Pp: 61-71
Vajir Malek, Nisha Sharma and Anil Bhanudas Gaikwad*
DOI: 10.2174/1874467212666181122092300

Preface promotion: free to download

Volume: 12   Issue: 1
Pp: 1-1
Michael Kahn
DOI: 10.2174/187446721201190103111612

Therapeutic Promises of Chlorogenic Acid with Special Emphasis on its Anti-Obesity Property

Volume: 12   Issue:
Pp: 1-10
Rajnish Kumar, Anju Sharma, Mohammed Shariq Iqbal and Janmejai K. Srivastava*
DOI: 10.2174/1874467212666190716145210

Diazoxide Modulates Cardiac Hypertrophy by Targeting H2O2 Generation and Mitochondrial Superoxide Dismutase Activity

Volume: 12   Issue:
Pp: 1-8
Aline Maria Brito Lucas, Joana Varlla de Lacerda Alexandre, Maria Thalyne Silva Araújo, Cicera Edna Barbosa David, Yuana Ivia Pontes Viana, Beatriz Neves Coelho, Francisco Rodrigo Lemos Caldas, Anna Lídia Nunes Varela, Alicia Juliana Kowaltowski and Heberty Tarso Facundo*
DOI: 10.2174/1874467212666190723144006

Protein Tyrosine Phosphatase (PTP1B): A promising Drug Target Against Life-threatening Ailments

Volume: 12   Issue:
Pp: 1-14
Ajay Kumar, Divya Rana, Rajat Rana and Rohit Bhatia*
DOI: 10.2174/1874467212666190724150723

The Role of Autophagy in Cancer Radiotherapy

Volume: 12   Issue:
Pp: 1-10
Lei Li*, Wen-Ling Liu, Lei Su, Zhou-Cheng Lu and Xiu-Sheng He*
DOI: 10.2174/1874467212666190809154518

Development, Characterization and Evaluation of In Vivo Anti-Tumor Activity of Niclosamide Nanoliposomes Against Colon Carcinoma

Volume: 12   Issue:
Pp: 1-8
Mahdi Hatamipour, Mahmoud R. Jaafari, Amir Abbas Momtazi-Borojeni, Mahin Ramezani and Amirhossein Sahebkar*
DOI: 10.2174/1874467212666190821142721

Mitotherapy as a Novel Therapeutic Strategy for Mitochondrial Diseases

Volume: 12   Issue:
Pp: 1-9
Ailing Fu*
DOI: 10.2174/1874467212666190920144115

Hepatic Nuclear Factor 1 Alpha (HNF-1α) In Human Physiology and Molecular Medicine

Volume: 12   Issue:
Pp: 1-7
Sumreen Begum*
DOI: 10.2174/1874467212666190930144349

Effects of Adipocyte-derived Factors on the Adrenal Cortex

Volume: 12   Issue:
Pp: 1-5
Hiroki Shimada, Erika Noro, Susumu Suzuki, Jun Sakamoto, Ikuko Sato, Rehana Parvin, Atsushi Yokoyama and Akira Sugawara*
DOI: 10.2174/1874467212666191015161334

Discovering Therapeutic Protein Targets for Bladder Cancer Using Proteomic Data Analysis

Volume: 12   Issue:
Pp: 1-23
Samira Bahrami, Bahram Kazemi*, Hakimeh Zali, Peter C. Black, Abbas Basiri, Mojgan Bandehpour, Mehdi Hedayati and Amirhossein Sahebkar
DOI: 10.2174/1874467212666191016124935

AdipoRon; A Novel Insulin Sensitizer in Various Complications and the Underlying Mechanisms: A Review

Volume: 12   Issue:
Pp: 1-1
Ishfaq Ahmad Bhat, Shaheen Wasil Kabeer, Mohammad Irshad Reza, Reyaz Hassan Mir* and Muhammad Ovais Dar
DOI: 10.2174/1874467212666191022102800

The Protective Effect of Cilostazol in Genotoxicity Induced by Methotrexate in Human Cultured Lymphocytes

Volume: 12   Issue:
Pp: 1-7
Abeer M. Rababa’h*, Samah A. Hussein, Omar F. Khabour and Karem H. Alzoubi
DOI: 10.2174/1874467212666191023120118

Small interfering RNAs and their delivery systems: A novel powerful tool for the potential treatment of HIV infections

Volume: 12   Issue:
Pp: 1-1
Azam Bolhassani* and Alireza Milani
DOI: 10.2174/1874467212666191023120954

Detailed Molecular Biochemistry for Novel Therapeutic Design Against Nipah and Hendra Virus: A Systematic Review

Volume: 12   Issue:
Pp: 1-18
Shreya Bhattacharya, Shreyeshi Dhar, Arundhati Banerjee and Sujay Ray*
DOI: 10.2174/1874467212666191023123732

Vasorelaxant Effect of Novel Nitric Oxide-Hydrogen Sulfide Donor Chalcone in isolated rat aorta: Involvement of cGMP mediated sGC and Potassium Channel Activation

Volume: 12   Issue:
Pp: 1-1
Amol Sherikar*, Rakesh Dhavale and Manish Bhatia
DOI: 10.2174/1874467212666191025092346

2-Aminoethyldiphenyl Borinate: A Multitarget Compound with Potential as a Drug Precursor

Volume: 12   Issue:
Pp: 1-19
Melvin N. Rosalez, Elizabeth Estevez-Fregoso, Alberto Alatorre, Antonio Abad-García and Marvin A. Soriano-Ursúa*
DOI: 10.2174/1874467212666191025145429

The Molecular and Enzyme Kinetic Basis for Altered Activity of Three Cytochrome P450 2C19 Variants Found in Chinese Population

Volume: 12   Issue:
Pp: 1-1
Amelia Nathania Dong, Nafees Ahemad, Yan Pan, Uma Devi Palanisamy, Beow Chin Yiap and Chin Eng Ong*
DOI: 10.2174/1874467212666191111110429

FAT10: Function and relationship with cancer

Volume: 12   Issue:
Pp: 1-1
Senfeng Xiang, Xuejing Shao, Ji Cao, Bo Yang, Qiaojun He and Meidan Ying*
DOI: 10.2174/1874467212666191113130312

Impact of spironolactone on markers of myocardial oxidative status, inflammation and remodeling in hyperthyroid rats.

Volume: 12   Issue:
Pp: 1-1
Fadia A Mayyas*, Ahmad I Aljohmani and Karem H Alzoubi
DOI: 10.2174/1874467212666191113150553

miR-4319 suppresses the growth of esophageal squamous cell carcinoma via targeting NLRC5

Volume: 12   Issue:
Pp: 1-1
Xiao Hu, Min Wang, Lei Cao, Li Cong, Yujie Gao, Jianwei Lu, Jifeng Feng, Bo Shen and Delin Liu*
DOI: 10.2174/1874467212666191119094636

Therapeutic targets for the treatment of comorbidities associated with epilepsy

Volume: 12   Issue:
Pp: 1-1
Kinjal Gangar and Lokesh Kumar Bhatt*
DOI: 10.2174/1874467212666191203101606

Phagocytosis and Motility in Human Neutrophils is Competent but Compromised by Pharmacological Inhibition of Ezrin Phosphorylation

Volume: 11   Issue: 4
Pp: 305-315
Rhiannon E. Roberts, Geetha L. Elumalai and Maurice B. Hallett*
DOI: 10.2174/1874467211666180516100613

Impact of Sphingolipid Mediators on the Determination of Cochlear Survival in Ototoxicity

Volume: 11   Issue: 4
Pp: 279-284
Keiji Tabuchi* and Akira Hara
DOI: 10.2174/1874467211666180516101111

Sepsis: The Involvement of Platelets and the Current Treatments

Volume: 11   Issue: 4
Pp: 261-269
Ana Carolina Antunes Naime, Jessica Oliveira Frade Ganaes and Maria Elisa Lopes-Pires*
DOI: 10.2174/1874467211666180619124531

Radiation Protection and Mitigation by Natural Antioxidants and Flavonoids: Implications to Radiotherapy and Radiation Disasters

Volume: 11   Issue: 4
Pp: 285-304
Rasoul Yahyapour, Dheyauldeen Shabeeb, Mohsen Cheki, Ahmed Eleojo Musa, Bagher Farhood, Abolhasan Rezaeyan, Peyman Amini, Hengameh Fallah and Masoud Najafi*
DOI: 10.2174/1874467211666180619125653

Anticancer Mechanism of Lobaplatin as Monotherapy and in Combination with Paclitaxel in Human Gastric Cancer open access plus

Volume: 11   Issue: 4
Pp: 316-325
Suhang Hua, Xiangyu Kong, Binbin Chen, Wenxin Zhuang, Qian Sun, Wei Yang, Wenzhi Liu* and Yongxing Zhang*
DOI: 10.2174/1874467211666180813095050

Tools in the Design of Therapeutic Drugs for CNS Disorders: An up-to-date Review

Volume: 11   Issue: 4
Pp: 270-278
Jagdish Kumar Sahu* and Arun Kumar Mishra
DOI: 10.2174/1874467211666180821101158

The Effect of Melatonin on Superoxide Dismutase and Glutathione Peroxidase Activity, and Malondialdehyde Levels in the Targeted and the Non-targeted Lung and Heart Tissues after Irradiation in Xenograft Mice Colon Cancer

Volume: 11   Issue: 4
Pp: 326-335
Seyede Hadis Momeni Hasan Abadi, Alireza Shirazi*, Ali Mohammad Alizadeh, Vahid Changizi, Masoud Najafi, Solmaz Khalighfard and Hasan Nosrati
DOI: 10.2174/1874467211666180830150154

The Role of SAPK/JNK Pathway in the Synergistic Effects of Metformin and Dacarbazine on Apoptosis in Raji and Ramos Lymphoma Cells

Volume: 11   Issue: 4
Pp: 336-342
Maryam Naserian, Elham Ramazani, Mehrdad Iranshahi and Zahra Tayarani-Najaran*
DOI: 10.2174/1874467211666180830150546

Acknowledgements to Reviewers promotion: free to download

Volume: 11   Issue: 4
Pp: 343-343

DOI: 10.2174/187446721104180924151255

Socialization Alleviates Burden of Oxidative-Stress in Hippocampus and Prefrontal Cortex in Morphine Addiction Period in Male Rats

Volume: 11   Issue: 3
Pp: 254-259
Hamidreza Famitafreshi and Morteza Karimian*
DOI: 10.2174/1874467210666170919161045

Targeting of Inflammation for Radiation Protection and Mitigation

Volume: 11   Issue: 3
Pp: 203-210
Rasoul Yahyapour, Peyman Amini, Saeed Rezapoor, Abolhasan Rezaeyan, Bagher Farhood, Mohsen Cheki, Hengameh Fallah and Masoud Najafi*
DOI: 10.2174/1874467210666171108165641

Targeting M3 Muscarinic Receptors for Colon Cancer Therapy

Volume: 11   Issue: 3
Pp: 184-190
Jessica Felton, Shien Hu and Jean-Pierre Raufman*
DOI: 10.2174/1874467211666180119115828

L-Sulforaphane Confers Protection Against Oxidative Stress in an In Vitro Model of Age-Related Macular Degeneration

Volume: 11   Issue: 3
Pp: 237-253
Nabeela K. Dulull, Daniel A. Dias, Thilini R. Thrimawithana and Faith A.A. Kwa*
DOI: 10.2174/1874467211666180125163009

COX-2 in Radiotherapy: A Potential Target for Radioprotection and Radiosensitization

Volume: 11   Issue: 3
Pp: 173-183
Mohsen Cheki, Rasoul Yahyapour, Bagher Farhood, Abolhassan Rezaeyan, Dheyauldeen Shabeeb, Peyman Amini, Saeed Rezapoor and Masoud Najafi*
DOI: 10.2174/1874467211666180219102520

Protein Tyrosine Phosphatase as Potential Therapeutic Target in various Disorders

Volume: 11   Issue: 3
Pp: 191-202
Shivani Verma and Saurabh Sharma*
DOI: 10.2174/1874467211666180226161846

Transdermal Delivery of AT1 Receptor Antagonists Reduce Blood Pressure and Reveal a Vasodilatory Effect on Kidney Blood Vessels

Volume: 11   Issue: 3
Pp: 226-236
Michaila Michalatou, Maria Eleni Androutsou, Markos Antonopoulos, Demetrios V. Vlahakos, George Agelis, Anthony Zulli, Tawar Qaradakhi, Kathleen Mikkelsen, Vasso Apostolopoulos* and John Matsoukas*
DOI: 10.2174/1874467211666180419152036

Tandem Mass Spectrometric Cell Wall Proteome Profiling of a Candida albicans hwp2 Mutant Strain

Volume: 11   Issue: 3
Pp: 211-225
Andy Awad, Pamela El Khoury, Brigitte Wex and Roy A. Khalaf*
DOI: 10.2174/1874467211666180509153228

Meet Our Editorial Board Member promotion: free to download

Volume: 11   Issue: 3
Pp: 171-172
Ricardo Jorge Dinis-Oliveira
DOI: 10.2174/187446721103180702152328

Umbelliferone Decreases Intracellular pH and Sensitizes Melanoma Cell Line A375 to Dacarbazin. Comparison with Acetazolamide promotion: free to download

Volume: 11   Issue: 2
Pp: 133-139
Clementine Puech*, Morgane Chatard, Delphine Felder-Flesch, Nathalie Prevot and Nathalie Perek*
DOI: 10.2174/1874467208666161128152518

Molecular Insights of CREB and MAP-K Phosphorylation by Modafinil in Wake-Related Brain Areas promotion: free to download

Volume: 11   Issue: 2
Pp: 140-148
Ramses Jimenez-Moreno, Adrian A. Farret-Ramos, Adriana Valle-Ayala, Niurka Trujillo-Paredes and Eric Murillo-Rodriguez*
DOI: 10.2174/1874467209666161214152006

The Non-Genomic Effects of the PPARβγ Agonist GW0742 on Streptozotocin Treated Rat Aorta promotion: free to download

Volume: 11   Issue: 2
Pp: 149-154
Noelia Perez-Diaz, Igor Pushkarsky, Nadia Oweis, Lisa A. Lione and Louise S. Mackenzie*
DOI: 10.2174/1874467209666161229124356