Current Molecular Pharmacology

Histone Acetylation Regulates Natriuretic Peptides and Neprilysin Gene Expressions in Diabetic Cardiomyopathy and Nephropathy

Volume: 12   Issue:
Pp: 1-11
Vajir Malek, Nisha Sharma and Anil Bhanudas Gaikwad*
DOI: 10.2174/1874467212666181122092300

Does the Development of Vaccines Advance Solutions for Tuberculosis?

Volume: 12   Issue:
Pp: 1-22
Manaf AlMatar*, Essam A. Makky, Husam AlMandeal, Emel Eker, Begüm Kayar, Işιl Var and Fatih Köksal
DOI: 10.2174/1874467212666181126151948

Mitochondria-Targeted Drugs

Volume: 12   Issue:
Pp: 1-13
Roman A. Zinovkin* and Andrey A. Zamyatnin*
DOI: 10.2174/1874467212666181127151059

MiR-597 targeting 14-3-3σ enhances cellular invasion and EMT in Nasopharyngeal carcinoma cells

Volume: 12   Issue:
Pp: 1-1
Lisha Xie, Tao Jiang, Ailan Cheng, Ting Zhang, Pin Huan, Pei Li, Gebo Wen, Fanghong Lei, Yun Huang, Xia Tang, Jie Gong, Yunpeng Lin, Jianke Kuai* and Weiguo Huang*
DOI: 10.2174/1874467212666181218113930

Phagocytosis and Motility in Human Neutrophils is Competent but Compromised by Pharmacological Inhibition of Ezrin Phosphorylation

Volume: 11   Issue: 4
Pp: 305-315
Rhiannon E. Roberts, Geetha L. Elumalai and Maurice B. Hallett*
DOI: 10.2174/1874467211666180516100613

Impact of Sphingolipid Mediators on the Determination of Cochlear Survival in Ototoxicity open access plus

Volume: 11   Issue: 4
Pp: 279-284
Keiji Tabuchi* and Akira Hara
DOI: 10.2174/1874467211666180516101111

Sepsis: The Involvement of Platelets and the Current Treatments

Volume: 11   Issue: 4
Pp: 261-269
Ana Carolina Antunes Naime, Jessica Oliveira Frade Ganaes and Maria Elisa Lopes-Pires*
DOI: 10.2174/1874467211666180619124531

Radiation Protection and Mitigation by Natural Antioxidants and Flavonoids: Implications to Radiotherapy and Radiation Disasters

Volume: 11   Issue: 4
Pp: 285-304
Rasoul Yahyapour, Dheyauldeen Shabeeb, Mohsen Cheki, Ahmed Eleojo Musa, Bagher Farhood, Abolhasan Rezaeyan, Peyman Amini, Hengameh Fallah and Masoud Najafi*
DOI: 10.2174/1874467211666180619125653

Anticancer Mechanism of Lobaplatin as Monotherapy and in Combination with Paclitaxel in Human Gastric Cancer open access plus

Volume: 11   Issue: 4
Pp: 316-325
Suhang Hua, Xiangyu Kong, Binbin Chen, Wenxin Zhuang, Qian Sun, Wei Yang, Wenzhi Liu* and Yongxing Zhang*
DOI: 10.2174/1874467211666180813095050

Tools in the Design of Therapeutic Drugs for CNS Disorders: An up-to-date Review

Volume: 11   Issue: 4
Pp: 270-278
Jagdish Kumar Sahu* and Arun Kumar Mishra
DOI: 10.2174/1874467211666180821101158

The Effect of Melatonin on Superoxide Dismutase and Glutathione Peroxidase Activity, and Malondialdehyde Levels in the Targeted and the Non-targeted Lung and Heart Tissues after Irradiation in Xenograft Mice Colon Cancer

Volume: 11   Issue: 4
Pp: 326-335
Seyede Hadis Momeni Hasan Abadi, Alireza Shirazi*, Ali Mohammad Alizadeh, Vahid Changizi, Masoud Najafi, Solmaz Khalighfard and Hasan Nosrati
DOI: 10.2174/1874467211666180830150154

The Role of SAPK/JNK Pathway in the Synergistic Effects of Metformin and Dacarbazine on Apoptosis in Raji and Ramos Lymphoma Cells

Volume: 11   Issue: 4
Pp: 336-342
Maryam Naserian, Elham Ramazani, Mehrdad Iranshahi and Zahra Tayarani-Najaran*
DOI: 10.2174/1874467211666180830150546

Acknowledgements to Reviewers promotion: free to download

Volume: 11   Issue: 4
Pp: 343-343

DOI: 10.2174/187446721104180924151255

Socialization Alleviates Burden of Oxidative-Stress in Hippocampus and Prefrontal Cortex in Morphine Addiction Period in Male Rats open access plus

Volume: 11   Issue: 3
Pp: 254-259
Hamidreza Famitafreshi and Morteza Karimian*
DOI: 10.2174/1874467210666170919161045

Targeting of Inflammation for Radiation Protection and Mitigation

Volume: 11   Issue: 3
Pp: 203-210
Rasoul Yahyapour, Peyman Amini, Saeed Rezapoor, Abolhasan Rezaeyan, Bagher Farhood, Mohsen Cheki, Hengameh Fallah and Masoud Najafi*
DOI: 10.2174/1874467210666171108165641

Targeting M3 Muscarinic Receptors for Colon Cancer Therapy open access plus

Volume: 11   Issue: 3
Pp: 184-190
Jessica Felton, Shien Hu and Jean-Pierre Raufman*
DOI: 10.2174/1874467211666180119115828

L-Sulforaphane Confers Protection Against Oxidative Stress in an In Vitro Model of Age-Related Macular Degeneration

Volume: 11   Issue: 3
Pp: 237-253
Nabeela K. Dulull, Daniel A. Dias, Thilini R. Thrimawithana and Faith A.A. Kwa*
DOI: 10.2174/1874467211666180125163009

COX-2 in Radiotherapy: A Potential Target for Radioprotection and Radiosensitization

Volume: 11   Issue: 3
Pp: 173-183
Mohsen Cheki, Rasoul Yahyapour, Bagher Farhood, Abolhassan Rezaeyan, Dheyauldeen Shabeeb, Peyman Amini, Saeed Rezapoor and Masoud Najafi*
DOI: 10.2174/1874467211666180219102520

Protein Tyrosine Phosphatase as Potential Therapeutic Target in various Disorders

Volume: 11   Issue: 3
Pp: 191-202
Shivani Verma and Saurabh Sharma*
DOI: 10.2174/1874467211666180226161846

Transdermal Delivery of AT1 Receptor Antagonists Reduce Blood Pressure and Reveal a Vasodilatory Effect on Kidney Blood Vessels

Volume: 11   Issue: 3
Pp: 226-236
Michaila Michalatou, Maria Eleni Androutsou, Markos Antonopoulos, Demetrios V. Vlahakos, George Agelis, Anthony Zulli, Tawar Qaradakhi, Kathleen Mikkelsen, Vasso Apostolopoulos* and John Matsoukas*
DOI: 10.2174/1874467211666180419152036

Tandem Mass Spectrometric Cell Wall Proteome Profiling of a Candida albicans hwp2 Mutant Strain

Volume: 11   Issue: 3
Pp: 211-225
Andy Awad, Pamela El Khoury, Brigitte Wex and Roy A. Khalaf*
DOI: 10.2174/1874467211666180509153228

Meet Our Editorial Board Member promotion: free to download

Volume: 11   Issue: 3
Pp: 171-172
Ricardo Jorge Dinis-Oliveira
DOI: 10.2174/187446721103180702152328

Umbelliferone Decreases Intracellular pH and Sensitizes Melanoma Cell Line A375 to Dacarbazin. Comparison with Acetazolamide promotion: free to download

Volume: 11   Issue: 2
Pp: 133-139
Clementine Puech*, Morgane Chatard, Delphine Felder-Flesch, Nathalie Prevot and Nathalie Perek*
DOI: 10.2174/1874467208666161128152518

Molecular Insights of CREB and MAP-K Phosphorylation by Modafinil in Wake-Related Brain Areas promotion: free to download

Volume: 11   Issue: 2
Pp: 140-148
Ramses Jimenez-Moreno, Adrian A. Farret-Ramos, Adriana Valle-Ayala, Niurka Trujillo-Paredes and Eric Murillo-Rodriguez*
DOI: 10.2174/1874467209666161214152006

The Non-Genomic Effects of the PPARβγ Agonist GW0742 on Streptozotocin Treated Rat Aorta promotion: free to download

Volume: 11   Issue: 2
Pp: 149-154
Noelia Perez-Diaz, Igor Pushkarsky, Nadia Oweis, Lisa A. Lione and Louise S. Mackenzie*
DOI: 10.2174/1874467209666161229124356

Prooxidant-Antioxidant Balance and Antioxidant Properties of Thuja orientalis L: A Potential Therapeutic Approach for Diabetes Mellitus promotion: free to download

Volume: 11   Issue: 2
Pp: 109-112
Daryoush H. Alamdari*, Malihe Aghasizadeh-Sharbaf, Maryam Mohadjerani, Gordon A. Ferns and Amir Avan
DOI: 10.2174/1874467210666170404112211

Opioids in the Frame of New Psychoactive Substances Network: A Complex Pharmacological and Toxicological Issue promotion: free to download

Volume: 11   Issue: 2
Pp: 97-108
Ludovic Ventura, Felix Carvalho and Ricardo Jorge Dinis-Oliveira*
DOI: 10.2174/1874467210666170704110146

The Nephroprotective Effect of N-Acetyl-L-Cysteine and Atorvastatin against Imipenem induced Nephrotoxicity promotion: free to download

Volume: 11   Issue: 2
Pp: 155-161
Abeer M. Rababa`h*, Tamara B. Hijjawi, Karem H. Alzoubi, Saddam Al Demour and Mera A. Ababneh
DOI: 10.2174/1874467210666170731115928

Characterization of Imatinib Resistant CML Leukemic Stem/Initiating Cells and Their Sensitivity to CBP/Catenin Antagonists promotion: free to download

Volume: 11   Issue: 2
Pp: 113-121
Yi Zhao, Kaijin Wu, Yongfeng Wu, Elizabeth Melendez, Goar Smbatyan, David Massiello and Michael Kahn*
DOI: 10.2174/1874467210666170919155739

MG17, A Novel Triazole Derivative Abrogated Neuroinflammation and Related Neurodegenerative Symptoms in Rodents promotion: free to download

Volume: 11   Issue: 2
Pp: 122-132
Gangadhar Matharasala, Ganesh Samala and Yogeeswari Perumal*
DOI: 10.2174/1874467210666170919160245

Gamma-Decanolactone Improves Biochemical Parameters Associated with Pilocarpine-Induced Seizures in Male Mice promotion: free to download

Volume: 11   Issue: 2
Pp: 162-169
Pricila Pfluger, Gabriela Gregory Regner, Vanessa Rodrigues Coelho, Lucas Lima da Silva, Leopoldo Nascimento, Cassiana Macagnan Viau, Regis Adriel Zanette, Cleonice Hoffmann, Jaqueline Nascimento Picada, Jenifer Saffi and Patricia Pereira*
DOI: 10.2174/1874467210666171002114954

MicroRNAs, Cancer and Diet: Facts and New Exciting Perspectives promotion: free to download

Volume: 11   Issue: 2
Pp: 90-96
Maria L. Motti, Stefania D`Angelo and Rosaria Meccariello*
DOI: 10.2174/1874467210666171013123733

Meet Our Editorial Board Member promotion: free to download

Volume: 11   Issue: 2
Pp: 89-89
Derek S. Tan
DOI: 10.2174/187446721102180410101917

Mechanisms for Radioprotection by Melatonin; Can it be Used as a Radia-tion Countermeasure?

Volume: 11   Issue:
Pp: 1-10
Peyman Amini, Hanifeh Mirtavoos-mahyari, Elahe Motevaseli, Dheyauldeen Shabeeb, Ahmed Eleojo Musa, Mohsen Cheki, Bagher Farhood, Rasoul Yahyapour, Alireza Shirazi, Nouraddin Abdi Goushbolagh and Masoud Najafi*
DOI: 10.2174/1874467211666180802164449

Pharmacokinetic and Pharmacodynamic Aspects of Peyote and Mescaline: Clinical and Forensic Repercussions

Volume: 11   Issue:
Pp: 1-11
Ricardo Jorge Dinis-Oliveira*, Carolina Lanca Pereira and Diana Dias da Silva
DOI: 10.2174/1874467211666181010154139

NADPH Oxidase as a Target for Modulation of Radiation Response; Implications to Carcinogenesis and Radiotherapy

Volume: 11   Issue:
Pp: 1-11
Keywan Mortezaee, Nasser Hashemi Goradel, Peyman Amini, Dheyauldeen Shabeeb, Ahmed Eleojo Musa, Masoud Najafi* and Bagher Farhood*
DOI: 10.2174/1874467211666181010154709

Combination Treatment of p53-Null HL-60 cells with Histone Deacetylase Inhibitors and Chlorambucil Augments Apoptosis and Increases BCL6 and p21 Gene Expression

Volume: 11   Issue:
Pp: 1-10
Faith A. A. Kwa*, Merrole F. Cole-Sinclair and Miroslav K. Kapuscinski
DOI: 10.2174/1874467211666181010161836

Curcuminoids and Novel Opportunities for the Treatment of Alzheimer's Disease: Which Molecules are Actually Effective?

Volume: 11   Issue:
Pp: 1-15
Alexander V. Zholos, Olesia F. Moroz and Maksim V. Storozhuk*
DOI: 10.2174/1874467211666181012150847

Kinase Targets for Mycolic Acid Biosynthesis in Mycobacterium tuberculosis

Volume: 11   Issue:
Pp: 1-23
Shahinda S.R. Alsayed, Chau Chun Beh, Neil R. Foster, Alan D. Payne, Yu Yu and Hendra Gunosewoyo*
DOI: 10.2174/1874467211666181025141114

The Role of Androgen Under Normal and Pathological Conditions in Sebaceous Glands: The Possibility of Target Therapy

Volume: 9   Issue: 4
Pp: 311-319
Abdullah Azmahani, Yasuhiro Nakamura, Keely M. McNamara and Hironobu Sasano
DOI: 10.2174/1874467208666150710120217

Stem Cell Therapy and Immunological Rejection in Animal Models open access plus

Volume: 9   Issue: 4
Pp: 284-288
Xiaowei Jin, Tongxiang Lin and Yang Xu
DOI: 10.2174/1874467208666150928153511

Mesenchymal Stem Cells and Cell Therapy for Bone Repair

Volume: 9   Issue: 4
Pp: 289-299
Shihua Wang, Pengchao Xu, Xiaoxia Li, Xiaodong Su, Yunfei Chen, Li Wan, Linyuan Fan, Kan Yin, Yan Liu and Robert Chunhua Zhao
DOI: 10.2174/1874467208666150928153758

microRNAs and Molecular Pathogenesis of Microcephaly

Volume: 9   Issue: 4
Pp: 300-304
Xuqing Liu and Tao Sun
DOI: 10.2174/1874467208666150928153949

In vitro Differentiation of Germ Cells from Stem Cells

Volume: 9   Issue: 4
Pp: 305-310
Xinbao Ding, Jian Wang and Ji Wu
DOI: 10.2174/1874467208666150928154053

Role of Hexokinase and VDAC in Neurological Disorders

Volume: 9   Issue: 4
Pp: 320-331
José César Rosa and Marcelo de Cerqueira César
DOI: 10.2174/1874467209666160112123036

Relationship Between Susceptibility to DMCM-Induced Generalized Motor Convulsions and Low-Affinity [3H]-Ouabain Binding in Membranes in Rat Brain

Volume: 9   Issue: 4
Pp: 332-336
Marcos Brandao Contó and Marco Antonio Campana Venditti
DOI: 10.2174/1874467209666160408152558

Synergistic Effects of Social Isolation and Morphine Addiction on Reduced Neurogenesis and BDNF Levels and the Resultant Deficits in Cognition and Emotional State in Male Rats

Volume: 9   Issue: 4
Pp: 337-347
Hamidreza Famitafreshi, Morteza Karimian and Sulail Fatima
DOI: 10.2174/1874467209666160822102153

Regulation of NF-κB signalling cascade by immunophilins

Volume: 9   Issue: 2
Pp: 99-108
Mariana Lagadari, Sonia A. De Leo, Maria F. Camisay, Mario D. Galigniana and Alejandra G. Erlejman
DOI: 10.2174/1874467208666150519113833

Therapeutic Targeting of the FKBP52 Co-Chaperone in Steroid Hormone Receptor-Regulated Physiology and Disease

Volume: 9   Issue: 2
Pp: 109-125
Naihsuan C. Guy, Yenni A. Garcia and Marc B. Cox
DOI: 10.2174/1874467208666150519114115

The FKBP51-Glucocorticoid Receptor Balance in Stress-Related Mental Disorders

Volume: 9   Issue: 2
Pp: 126-140
Gabriel R. Fries, Nils C. Gassen, Ulrike Schmidt and Theo Rein
DOI: 10.2174/1874467208666150519114435

Molecular Aspects of FKBP51 that Enable Melanoma Dissemination

Volume: 9   Issue: 2
Pp: 141-147
Anna D’Angelillo, Stefania Staibano, Michele Russo, Maria F. Romano and Simona Romano
DOI: 10.2174/1874467208666150519115242

Cyclophilin function in Cancer; lessons from virus replication

Volume: 9   Issue: 2
Pp: 148-164
Paul T.M. Lavin and Margaret M. Mc Gee
DOI: 10.2174/1874467208666150519115443

The Role of Peptidyl Prolyl Isomerases in Aging and Vascular Diseases

Volume: 9   Issue: 2
Pp: 165-179
Lana McClements, Stephanie Annett, Anita Yakkundi and Tracy Robson
DOI: 10.2174/1874467208666150519115729

Conformational Dynamics in FKBP Domains: Relevance to Molecular Signaling and Drug Design promotion: free to download

Volume: 9   Issue: 1
Pp: 5-26
David M. LeMaster and Griselda Hernandez
DOI: 10.2174/1874467208666150519113146

Recent Progress in FKBP Ligand Development promotion: free to download

Volume: 9   Issue: 1
Pp: 27-36
Xixi Feng, Sebastian Pomplun and Felix Hausch
DOI: 10.2174/1874467208666150519113313

Immunophilins: Structures, Mechanisms and Ligands promotion: free to download

Volume: 9   Issue: 1
Pp: 37-47
Amaravadhi Harikishore and Ho Sup Yoon
DOI: 10.2174/1874467208666150519113427

FK506-Binding Proteins and Their Diverse Functions promotion: free to download

Volume: 9   Issue: 1
Pp: 48-65
Mingming Tong and Yu Jiang
DOI: 10.2174/1874467208666150519113541

Steroid Receptor-Associated Immunophilins: Candidates for Diverse Drug-Targeting Approaches in Disease promotion: free to download

Volume: 9   Issue: 1
Pp: 66-95
Thomas Ratajczak
DOI: 10.2174/1874467208666150519113639

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging

Volume: 8   Issue: 2
Pp: 206-222
Gaetano Santulli and Andrew R. Marks
DOI: 10.2174/1874467208666150507105105

Ca_v1.3 Channels as Key Regulators of Neuron-Like Firings and Catecholamine Release in Chromaffin Cells open access plus

Volume: 8   Issue: 2
Pp: 149-161
David H.F. Vandael, Andrea Marcantoni and Emilio Carbone
DOI: 10.2174/1874467208666150507105443

Pharmacology of L-type Calcium Channels: Novel Drugs for Old Targets? open access plus

Volume: 8   Issue: 2
Pp: 110-122
Jorg Striessnig, Nadine J. Ortner and Alexandra Pinggera
DOI: 10.2174/1874467208666150507105845

Towards a Unified Theory of Calmodulin Regulation (Calmodulation) of Voltage-Gated Calcium and Sodium Channels

Volume: 8   Issue: 2
Pp: 188-205
Manu Ben-Johny, Ivy E. Dick, Lingjie Sang, Worawan B. Limpitikul, Po Wei Kang, Jacqueline Niu, Rahul Banerjee, Wanjun Yang, Jennifer S. Babich, John B. Issa, Shin Rong Lee, Ho Namkung, Jiangyu Li, Manning Zhang, Philemon S. Yang, Hojjat Bazzazi, Paul J. Adams, Rosy Joshi-Mukherjee, Daniel N. Yue and David T. Yue
DOI: 10.2174/1874467208666150507110359

Calcium Channel Mutations in Cardiac Arrhythmia Syndromes

Volume: 8   Issue: 2
Pp: 133-142
Matthew J. Betzenhauser, Geoffrey S. Pitt and Charles Antzelevitch
DOI: 10.2174/1874467208666150518114857

CACNB2: An Emerging Pharmacological Target for Hypertension, Heart Failure, Arrhythmia and Mental Disorders promotion: free to download

Volume: 8   Issue: 1
Pp: 32-42
Nikolai M. Soldatov
DOI: 10.2174/1874467208666150507093258

Regulation of Cardiac Calcium Channels in the Fight-or-Flight Response promotion: free to download

Volume: 8   Issue: 1
Pp: 12-21
William A. Catterall
DOI: 10.2174/1874467208666150507103417