Abstract
In the vascular wall of large arteries, cellular and humoral immune responses are elicited as a consequence of diverse noxious stimuli within subendothelial space, which further derives in endothelial dysfunction, the accumulation of lipids and formation of the atheromatous plaque. Monocytes, macrophages, T cells, endothelial cells and smooth muscular cells are all players in this inflammatory-atherosclerotic process, which is not only genetically regulated but also influenced by environmental factors. In this review, the summary of genetic variants in major immune mediators associated with the evolution of atherosclerosis is presented.
Keywords: Atherosclerosis, genetic polymorphisms, inflammation, cytokines
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: Genetic Polymorphisms of Inflammatory Mediators in Atherosclerosis
Volume: 7 Issue: 3
Author(s): Ana Z. Fernandez
Affiliation:
Keywords: Atherosclerosis, genetic polymorphisms, inflammation, cytokines
Abstract: In the vascular wall of large arteries, cellular and humoral immune responses are elicited as a consequence of diverse noxious stimuli within subendothelial space, which further derives in endothelial dysfunction, the accumulation of lipids and formation of the atheromatous plaque. Monocytes, macrophages, T cells, endothelial cells and smooth muscular cells are all players in this inflammatory-atherosclerotic process, which is not only genetically regulated but also influenced by environmental factors. In this review, the summary of genetic variants in major immune mediators associated with the evolution of atherosclerosis is presented.
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Cite this article as:
Fernandez Z. Ana, Genetic Polymorphisms of Inflammatory Mediators in Atherosclerosis, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2008; 7 (3) . https://dx.doi.org/10.2174/187152308785699272
DOI https://dx.doi.org/10.2174/187152308785699272 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
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