Abstract
Polycystic ovary syndrome (PCOS) is one of the most frequent diseases that affects women in their reproductive age. The heterogeneity of PCOS makes not only the diagnosis but also the choice of an adequate treatment difficult. The biguanide, N, N’ dimethyl-biguanide : Metformin is an antidiabetic drug that increases glucose utilization in insulinsensitive tissues and is useful in the reduction of both insulin resistance and circulating androgens as well as restoring ovulation. However, metformin is being clinically used without a complete understanding of the mechanism involved. The present review explores some of the actions and efficacy of metformin in the treatment of PCOS during different reproductive periods.
Keywords: Polycystic ovary syndrome (PCOS), metformin, diabetes, adolescents, pregnancy, ovulation, cardiovascular
Current Pharmaceutical Design
Title: Metformin in the Treatment of Polycystic Ovary Syndrome
Volume: 14 Issue: 21
Author(s): Dra Alicia Beatriz Motta
Affiliation:
Keywords: Polycystic ovary syndrome (PCOS), metformin, diabetes, adolescents, pregnancy, ovulation, cardiovascular
Abstract: Polycystic ovary syndrome (PCOS) is one of the most frequent diseases that affects women in their reproductive age. The heterogeneity of PCOS makes not only the diagnosis but also the choice of an adequate treatment difficult. The biguanide, N, N’ dimethyl-biguanide : Metformin is an antidiabetic drug that increases glucose utilization in insulinsensitive tissues and is useful in the reduction of both insulin resistance and circulating androgens as well as restoring ovulation. However, metformin is being clinically used without a complete understanding of the mechanism involved. The present review explores some of the actions and efficacy of metformin in the treatment of PCOS during different reproductive periods.
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Cite this article as:
Beatriz Motta Alicia Dra, Metformin in the Treatment of Polycystic Ovary Syndrome, Current Pharmaceutical Design 2008; 14 (21) . https://dx.doi.org/10.2174/138161208785294609
DOI https://dx.doi.org/10.2174/138161208785294609 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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