Abstract
Over the past decade, several continuous glucose monitoring systems have been developed, representing remarkable technological achievements. Most of the systems monitor glucose invasively in the subcutaneous tissue. It is important to realize that there are discrepancies between blood and interstitial glucose concentration, which (1) may impact the quality of the system calibration and thereby the accuracy of the data, (2) may jeopardize the specificity and the sensitivity of hypoglycaemic alarms based on these systems and (3) must be considered in the design of closed-loop insulin delivery systems. The aim of this review is to make the point that the challenge of developing a continuous glucose monitoring system is not only technological, but must also take into account the physiology of glucose in alternate sites where it is sensed.
Keywords: Continuous glucose monitoring, Interstitial glucose, Push-pull phenomenon
Current Diabetes Reviews
Title: Continuous Glucose Monitoring: Physiological and Technological Challenges
Volume: 4 Issue: 3
Author(s): Gerard Reach and Carine Choleau
Affiliation:
Keywords: Continuous glucose monitoring, Interstitial glucose, Push-pull phenomenon
Abstract: Over the past decade, several continuous glucose monitoring systems have been developed, representing remarkable technological achievements. Most of the systems monitor glucose invasively in the subcutaneous tissue. It is important to realize that there are discrepancies between blood and interstitial glucose concentration, which (1) may impact the quality of the system calibration and thereby the accuracy of the data, (2) may jeopardize the specificity and the sensitivity of hypoglycaemic alarms based on these systems and (3) must be considered in the design of closed-loop insulin delivery systems. The aim of this review is to make the point that the challenge of developing a continuous glucose monitoring system is not only technological, but must also take into account the physiology of glucose in alternate sites where it is sensed.
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Cite this article as:
Reach Gerard and Choleau Carine, Continuous Glucose Monitoring: Physiological and Technological Challenges, Current Diabetes Reviews 2008; 4 (3) . https://dx.doi.org/10.2174/157339908785294488
DOI https://dx.doi.org/10.2174/157339908785294488 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
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