Abstract
The generation of an allergic immune response requires at least two signals for complete activation of T cells. Costimulatory molecules are integral to the second signal. In this review, we analyze the costimulatory molecule signaling lymphocytic activation molecule (SLAM) and other recently described SLAM family members. We highlight recent findings that position SLAM as critical for allergic inflammation and its role in modulation of cytokine secretion. Furthermore, a possible role of SLAM as a link between the adaptive and innate immune response is also discussed. Understanding the role of costimulatory molecules, including SLAM and SLAM family members, may elucidate mechanisms involved in the allergic immune response, and suggest potential therapeutic opportunities.
Keywords: Allergy, SLAM, SAP, XLP, costimulatory molecules
Current Molecular Medicine
Title: New Costimulatory Families: Signaling Lymphocytic Activation Molecule in Adaptive Allergic Responses
Volume: 8 Issue: 5
Author(s): Samir S. Makani, Kai Y. Jen and Patricia W. Finn
Affiliation:
Keywords: Allergy, SLAM, SAP, XLP, costimulatory molecules
Abstract: The generation of an allergic immune response requires at least two signals for complete activation of T cells. Costimulatory molecules are integral to the second signal. In this review, we analyze the costimulatory molecule signaling lymphocytic activation molecule (SLAM) and other recently described SLAM family members. We highlight recent findings that position SLAM as critical for allergic inflammation and its role in modulation of cytokine secretion. Furthermore, a possible role of SLAM as a link between the adaptive and innate immune response is also discussed. Understanding the role of costimulatory molecules, including SLAM and SLAM family members, may elucidate mechanisms involved in the allergic immune response, and suggest potential therapeutic opportunities.
Export Options
About this article
Cite this article as:
Makani S. Samir, Jen Y. Kai and Finn W. Patricia, New Costimulatory Families: Signaling Lymphocytic Activation Molecule in Adaptive Allergic Responses, Current Molecular Medicine 2008; 8 (5) . https://dx.doi.org/10.2174/156652408785161005
DOI https://dx.doi.org/10.2174/156652408785161005 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Inhibition of the VEGF/VEGFR Pathway Improves Survival in Advanced Kidney Cancer: A Systematic Review and Meta-Analysis
Current Drug Targets Nanotools for the Delivery of Antimicrobial Peptides
Current Drug Targets Natural Therapies of the Inflammatory Bowel Disease: The Case of Rutin and its Aglycone, Quercetin
Mini-Reviews in Medicinal Chemistry TGF-b: A Fibrotic Factor in Wound Scarring and a Potential Target for Anti- Scarring Gene Therapy
Current Gene Therapy Role of Adipocytokines in Hepatic Fibrosis
Current Pharmaceutical Design VEGF in Tumor Progression and Targeted Therapy
Current Cancer Drug Targets Inhibiting the Enzymes of the Endothelin and Renin-Angiotensin Systems in Cancer
Current Enzyme Inhibition The Potential for Genetically Altered Microglia to Influence Glioma Treatment
CNS & Neurological Disorders - Drug Targets Interstitial Lung Disease in Systemic Sclerosis: Pathophysiology, Current and New Advances in Therapy
Inflammation & Allergy - Drug Targets (Discontinued) Hyaluronic Acid/Parecoxib-Loaded PLGA Microspheres for Therapy of Temporomandibular Disorders
Current Drug Delivery Identification of Expressed miRNAs in Human Rheumatoid Arthritis Using Computational Approach – Discovery of a New miR-7167 from Human
MicroRNA Diagnostic Usefulness of Tumor Markers in the Thyroid Cytological Samples Extracted by Fine-Needle Aspiration Biopsy
Endocrine, Metabolic & Immune Disorders - Drug Targets Chemoprevention of Colorectal Cancer: Ready for Routine Use?
Current Topics in Medicinal Chemistry Yeast as a Humanized Model Organism for Biotransformation-Related Toxicity
Current Drug Metabolism Preface
Clinical Immunology, Endocrine & Metabolic Drugs (Discontinued) Meet Our Editorial Board Member:
Current Nutrition & Food Science Cytokine Expression Profile in Aqueous Humor and Sera of Patients with Acute Anterior Uveitis
Current Molecular Medicine Nutrigenomics and Its Approaches for Control of Chronic Diseases
Current Biotechnology Overview of the Structure and Function of Protein Kinases
Current Enzyme Inhibition In-silico & In-vitro Identification of Structure-Activity Relationship Pattern of Serpentine & Gallic Acid Targeting PI3Kγ as Potential Anticancer Target
Current Cancer Drug Targets