Abstract
Eicosanoids are diverse mediators of inflammation that derive from a single cell membrane phospholipid- associated precursor, arachidonic acid. This precursor is metabolized to several groups of lipid mediators, including (but not limited to) prostaglandins, leukotrienes, and lipoxins, in a tightly regulated, coordinated, cell- and context-specific manner. Each mediator serves regulatory and homeostatic functions in the onset and resolution of inflammation, immune responses, and tissue repair. The cloning of biosynthetic enzymes and G protein-coupled receptors for each of these mediators, the development of transgenic mice deficient in these molecules, and the availability of selective antagonists have permitted studies that have rapidly expanded our understanding of the scope of biologic functions for these mediators, with potential ramifications for the pathogenesis and treatment of human asthma. This review summarizes these findings and reviews the data from both mouse and human studies pertinent to the pathobiologic role of each mediator.
Keywords: Eicosanoids, leukotrienes, prostaglandins, lipoxins
Current Molecular Medicine
Title: Eicosanoids in Asthma, Allergic Inflammation, and Host Defense
Volume: 8 Issue: 5
Author(s): Joshua A. Boyce
Affiliation:
Keywords: Eicosanoids, leukotrienes, prostaglandins, lipoxins
Abstract: Eicosanoids are diverse mediators of inflammation that derive from a single cell membrane phospholipid- associated precursor, arachidonic acid. This precursor is metabolized to several groups of lipid mediators, including (but not limited to) prostaglandins, leukotrienes, and lipoxins, in a tightly regulated, coordinated, cell- and context-specific manner. Each mediator serves regulatory and homeostatic functions in the onset and resolution of inflammation, immune responses, and tissue repair. The cloning of biosynthetic enzymes and G protein-coupled receptors for each of these mediators, the development of transgenic mice deficient in these molecules, and the availability of selective antagonists have permitted studies that have rapidly expanded our understanding of the scope of biologic functions for these mediators, with potential ramifications for the pathogenesis and treatment of human asthma. This review summarizes these findings and reviews the data from both mouse and human studies pertinent to the pathobiologic role of each mediator.
Export Options
About this article
Cite this article as:
Boyce A. Joshua, Eicosanoids in Asthma, Allergic Inflammation, and Host Defense, Current Molecular Medicine 2008; 8 (5) . https://dx.doi.org/10.2174/156652408785160989
DOI https://dx.doi.org/10.2174/156652408785160989 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Tobacco, Inflammation, and Respiratory Tract Cancer
Current Pharmaceutical Design Passive Smoking, Asthma and Allergy in Children
Inflammation & Allergy - Drug Targets (Discontinued) Editorial (Thematic Issue: Therapeutic Applications of Advanced Drug Delivery Systems)
Current Pharmaceutical Design Prospective Plant Based Anticancer Lead Molecules
Current Topics in Medicinal Chemistry Preface:
Drug Metabolism Letters Food Selectivity, Gastrointestinal Symptoms and Urine Organic Acids in Autism Spectrum Disorder: A Pilot Study
Current Nutrition & Food Science Gene-environment Interactions in Late Life: Linking Psychosocial Stress with Brain Aging
Current Neuropharmacology A Possible Role for Interleukin 37 in the Pathogenesis of Behcet's Disease
Current Molecular Medicine Meet Our Editorial Board Member
Recent Patents on Inflammation & Allergy Drug Discovery Recent Advances in Oral Pulsatile Drug Delivery
Recent Patents on Drug Delivery & Formulation Molecular Allergy Diagnostics as an Adjunct to Conventional Diagnostics in a Secondary Pediatric Referral Center
Recent Patents on Inflammation & Allergy Drug Discovery The Relationship Between Cleft Lip, Maxillary Hypoplasia, Hypoxia and Phenytoin
Current Pharmaceutical Design The Use of Methotrexate in Respiratory Diseases
Current Respiratory Medicine Reviews Anti-Inflammatory Iridoids of Botanical Origin
Current Medicinal Chemistry Application of Chitosan and its Derivatives in Nanocarrier Based Pulmonary Drug Delivery Systems
Pharmaceutical Nanotechnology Pharmacogenomics and Personalized Medicine for the Developing World - Too Soon or Just-in-Time? A Personal View from the World Health Organization
Current Pharmacogenomics and Personalized Medicine Targeting TRP Channels in Airway Disorders
Current Topics in Medicinal Chemistry Bipolar Affective Disorder in Young People: A Review
Adolescent Psychiatry Impact of New Technologies on Pharmacogenomics
Current Pharmacogenomics and Personalized Medicine Nitrite-stimulated Gastric Formation of S-nitrosothiols As An Antihypertensive Therapeutic Strategy
Current Drug Targets