Abstract
Ceramide kinase (CERK) was discovered more than a decade ago. Since then, numerous reports have been published demonstrating a role for CERK in various signal transduction pathways involved in inflammation, immunity or cancer. In this review, the biosynthesis of ceramide-1-phosphate (C1P) and the various roles of CERK and C1P in biological mechanisms will be overviewed. We will focus on the role of C1P in eicosanoid synthesis, more specifically, in the activation and translocation of cPLA2α. Furthermore, the possible therapeutic relevance of inhibitors of these mechanisms is discussed.
Keywords: family transferase, biosynthesis, Ceramide Kinase, Ceramide-1-Phosphate/cPLA2α, Therapeutic Target, biological mechanisms, eicosanoid synthesis, calcium mobilization
Current Drug Targets
Title: Ceramide Kinase and the Ceramide-1-Phosphate/cPLA2α Interaction as a Therapeutic Target
Volume: 9 Issue: 8
Author(s): Nadia F. Lamour and Charles E. Chalfant
Affiliation:
Keywords: family transferase, biosynthesis, Ceramide Kinase, Ceramide-1-Phosphate/cPLA2α, Therapeutic Target, biological mechanisms, eicosanoid synthesis, calcium mobilization
Abstract: Ceramide kinase (CERK) was discovered more than a decade ago. Since then, numerous reports have been published demonstrating a role for CERK in various signal transduction pathways involved in inflammation, immunity or cancer. In this review, the biosynthesis of ceramide-1-phosphate (C1P) and the various roles of CERK and C1P in biological mechanisms will be overviewed. We will focus on the role of C1P in eicosanoid synthesis, more specifically, in the activation and translocation of cPLA2α. Furthermore, the possible therapeutic relevance of inhibitors of these mechanisms is discussed.
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Cite this article as:
Lamour F. Nadia and Chalfant E. Charles, Ceramide Kinase and the Ceramide-1-Phosphate/cPLA2α Interaction as a Therapeutic Target, Current Drug Targets 2008; 9 (8) . https://dx.doi.org/10.2174/138945008785132349
DOI https://dx.doi.org/10.2174/138945008785132349 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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