Abstract
The major role of memory T cells is to ensure protection upon re-exposure to pathogens through rapid clonal proliferation and functional activation. This immunity usually persists for periods which can extend for over 60 years. These memory T cells are generated during acute viral infections. In the context of influenza viral infection, the presence of neutralizing antibodies against influenza virus proteins provides the first line of defense that prevents viral colonization and replication. Long-lasting humoral protective immunity is also needed for protection. However, antibodies against one subtype are usually inefficient in providing protection against other subtypes in humans. Major cytotoxic T-cell responses are usually targeted against conserved internal viral proteins. Moreover, the generated CTL responses are cross-reactive between influenza subtypes. In this review, we will discuss the generation and persistence of memory T cells and the role they play during influenza viral infection. An overview of new vaccine approaches aiming at the development of protective T-cell immune memory against influenza infection will also be provided.
Keywords: Influenza viral infection, Effector memory T cells, Central memory T cells, Acute viral infection, chronic viral infections
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: Role of Memory T Cells in Influenza Viral Infection
Volume: 7 Issue: 2
Author(s): Rabih Halwani, Mehrnoosh Doroudchi, Mohamed El-Far, Andre Tanel, Yu Shi, Bader Yassine-Diab and Rafick-Pierre Sekaly
Affiliation:
Keywords: Influenza viral infection, Effector memory T cells, Central memory T cells, Acute viral infection, chronic viral infections
Abstract: The major role of memory T cells is to ensure protection upon re-exposure to pathogens through rapid clonal proliferation and functional activation. This immunity usually persists for periods which can extend for over 60 years. These memory T cells are generated during acute viral infections. In the context of influenza viral infection, the presence of neutralizing antibodies against influenza virus proteins provides the first line of defense that prevents viral colonization and replication. Long-lasting humoral protective immunity is also needed for protection. However, antibodies against one subtype are usually inefficient in providing protection against other subtypes in humans. Major cytotoxic T-cell responses are usually targeted against conserved internal viral proteins. Moreover, the generated CTL responses are cross-reactive between influenza subtypes. In this review, we will discuss the generation and persistence of memory T cells and the role they play during influenza viral infection. An overview of new vaccine approaches aiming at the development of protective T-cell immune memory against influenza infection will also be provided.
Export Options
About this article
Cite this article as:
Halwani Rabih, Doroudchi Mehrnoosh, El-Far Mohamed, Tanel Andre, Shi Yu, Yassine-Diab Bader and Sekaly Rafick-Pierre, Role of Memory T Cells in Influenza Viral Infection, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2008; 7 (2) . https://dx.doi.org/10.2174/187152308784533186
DOI https://dx.doi.org/10.2174/187152308784533186 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Targeting n-3 Polyunsaturated Fatty Acids in Non-Alcoholic Fatty Liver Disease
Current Medicinal Chemistry Antigenic Peptide Vaccination: Provoking Immune Response and Clinical Benefit for Cancer
Current Immunology Reviews (Discontinued) Biophysical Screening for Identifying Pharmacological Chaperones and Inhibitors Against Conformational and Infectious Diseases
Current Drug Targets A Rare Case of Drug-Induced Erectile Dysfunction with Secukinumab Solved After Switch to Ixekizumab in A Psoriatic Patient: A Case Report
Current Drug Safety Search for Potential Inducible Nitric Oxide Synthase Inhibitors with Favorable ADMET Profiles for the Therapy of Helicobacter pylori Infections
Current Topics in Medicinal Chemistry Microarray Analysis of Human Epithelial Cell Responses to Bacterial Interaction
Infectious Disorders - Drug Targets Role of Cellular Biomolecules in Screening, Diagnosis and Treatment of Colorectal Cancer
Current Drug Metabolism Caffeic Acid Phenethyl Ester Restores Adipocyte Gene Profile Expression Following Lipopolysaccharide Treatment
Letters in Drug Design & Discovery A Review on the Design, Synthesis, and Structure-activity Relationships of Benzothiazole Derivatives against Hypoxic Tumors
Current Organic Synthesis Patent Selections
Recent Patents on Anti-Cancer Drug Discovery Interconnection of Estrogen/Testosterone Metabolism and Mevalonate Pathway in Breast and Prostate Cancers
Current Molecular Pharmacology Phytotherapeutic Agents for Benign Prostatic Hyperplasia: An Overview
Mini-Reviews in Medicinal Chemistry Assessment of New E2 Protein Domain Interaction with PKR Protein to Control IFN Signaling
Current Proteomics Quercetin and Its Role in Reducing the Expression of Pro-inflammatory Cytokines in Osteoarthritis
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Insulin Regulation of PEPCK Gene Expression: A Model for Rapid and Reversible Modulation
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Hematopoietic Stem Cell Transplantation for the Treatment of Autoimmunity in Type 1 Diabetes
Current Stem Cell Research & Therapy How Important are S100A8/S100A9 Calcium Binding Proteins for the Activation of Phagocyte NADPH Oxidase, Nox2
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Hemolytic Uremic Syndrome in Children
Current Pediatric Reviews Vasopressin and Oxytocin in Control of the Cardiovascular System
Current Neuropharmacology Can Transcriptomics Cut the Gordian Knot of Amyotrophic Lateral Sclerosis?
Current Genomics