Abstract
Acute ischemic stroke is a leading cause of death and severe disability in industrialised countries and also in many developing countries. An excessive amount of free radicals is generated during cerebral ischemia, which significantly contributes to brain damage. Therefore, an increasing interest has been devoted to the potential benefits of antioxidant compounds in ischemic stroke patients. In this review, we examined the most relevant observational studies concerning the relationship between dietary antioxidants and ischemic stroke as well as clinical trials investigating the effects of single or multiple antioxidant supplementation in the prevention or treatment of acute ischemic stroke. Furthermore, we reviewed the most promising antioxidant compounds, i.e. dehydroascorbic acid, α-tocotrienol, γ- tocopherol, flavonoids, resveratrol and gingko biloba, tested in animal models of acute ischemic stroke. Finally, we carefully evaluated the reasons for the discrepancy between experimental and clinical studies, and provided recommendations to improve the translation of the results obtained in animal models to patients with acute ischemic stroke.
Keywords: Ginkgo Biloba, Vitamin C, Vitamin E Supplementation, Carotenoids, Flavonoids, Phytoestrogens
Current Medicinal Chemistry
Title: Dietary Antioxidants as Potential Pharmacological Agents for Ischemic Stroke
Volume: 15 Issue: 12
Author(s): A. Cherubini, C. Ruggiero, C. Morand, F. Lattanzio, G. Dell'Aquila, G. Zuliani, A. Di Iorio and C. Andres-Lacueva
Affiliation:
Keywords: Ginkgo Biloba, Vitamin C, Vitamin E Supplementation, Carotenoids, Flavonoids, Phytoestrogens
Abstract: Acute ischemic stroke is a leading cause of death and severe disability in industrialised countries and also in many developing countries. An excessive amount of free radicals is generated during cerebral ischemia, which significantly contributes to brain damage. Therefore, an increasing interest has been devoted to the potential benefits of antioxidant compounds in ischemic stroke patients. In this review, we examined the most relevant observational studies concerning the relationship between dietary antioxidants and ischemic stroke as well as clinical trials investigating the effects of single or multiple antioxidant supplementation in the prevention or treatment of acute ischemic stroke. Furthermore, we reviewed the most promising antioxidant compounds, i.e. dehydroascorbic acid, α-tocotrienol, γ- tocopherol, flavonoids, resveratrol and gingko biloba, tested in animal models of acute ischemic stroke. Finally, we carefully evaluated the reasons for the discrepancy between experimental and clinical studies, and provided recommendations to improve the translation of the results obtained in animal models to patients with acute ischemic stroke.
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Cite this article as:
Cherubini A., Ruggiero C., Morand C., Lattanzio F., Dell'Aquila G., Zuliani G., Iorio Di A. and Andres-Lacueva C., Dietary Antioxidants as Potential Pharmacological Agents for Ischemic Stroke, Current Medicinal Chemistry 2008; 15 (12) . https://dx.doi.org/10.2174/092986708784310431
DOI https://dx.doi.org/10.2174/092986708784310431 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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