Abstract
The management of renal cell carcinoma (RCC) has undergone rapid and radical evolution over the last few years. An improved understanding of the underlying biology of RCC has led to the approval of several new therapies directed against specific and relevant biological targets, so-called “targeted therapies.” These highly effective treatments are now entering routine use, however many questions still remain as to how best to use these agents and integrate them into the broader therapeutic armamentarium. This review summarizes the major published clinical trials of the new agents, discusses the controversies and research questions that have arisen as a result, and considers some of the issues that remain.
Keywords: Renal cell carcinoma, kidney cancer, angiogenesis, vasculature, stroma, kinase inhibitors, signal transduction inhibitors
Current Medicinal Chemistry
Title: Targeted Therapies in the Treatment of Renal Cell Carcinoma
Volume: 15 Issue: 12
Author(s): Carmel Pezaro and Ian D. Davis
Affiliation:
Keywords: Renal cell carcinoma, kidney cancer, angiogenesis, vasculature, stroma, kinase inhibitors, signal transduction inhibitors
Abstract: The management of renal cell carcinoma (RCC) has undergone rapid and radical evolution over the last few years. An improved understanding of the underlying biology of RCC has led to the approval of several new therapies directed against specific and relevant biological targets, so-called “targeted therapies.” These highly effective treatments are now entering routine use, however many questions still remain as to how best to use these agents and integrate them into the broader therapeutic armamentarium. This review summarizes the major published clinical trials of the new agents, discusses the controversies and research questions that have arisen as a result, and considers some of the issues that remain.
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Cite this article as:
Pezaro Carmel and Davis D. Ian, Targeted Therapies in the Treatment of Renal Cell Carcinoma, Current Medicinal Chemistry 2008; 15 (12) . https://dx.doi.org/10.2174/092986708784310440
DOI https://dx.doi.org/10.2174/092986708784310440 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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