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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Synthesis and Synthetic Applications of α-Amino Ketones Derived from Natural α-Amino Acids

Author(s): Jose M. Concellon and Humberto Rodriguez-Solla

Volume 12, Issue 7, 2008

Page: [524 - 543] Pages: 20

DOI: 10.2174/138527208784245996

Price: $65

Abstract

Enantiomerically pure α-amino ketones are of great importance in natural product synthesis and pharmacological research. However no review concerning their synthesis and applications has been published. Therefore, this review is intended to highlight the above compounds, detailing the available methodologies to prepare enantiopure α-amino ketones in the first part and some synthetic application in the second.

Keywords: organolithium reagents, amino ketones, Weinreb amides, chemical transformations, Reduction, Glycinamides


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