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Current Drug Metabolism

Editor-in-Chief

ISSN (Print): 1389-2002
ISSN (Online): 1875-5453

An Experimental Approach for the Study of Psychotropic Drug Effects Under Simulated Clinical Conditions

Author(s): N. N. Kudryavtseva, D. F. Avgustinovich, N. P. Bondar, M. V. Tenditnik and I. L. Kovalenko

Volume 9, Issue 4, 2008

Page: [352 - 360] Pages: 9

DOI: 10.2174/138920008784220592

Price: $65

Abstract

The sensory contact model can induce various different psychopathological states in male mice (anxious depression, catalepsy, social withdrawal, pathological aggression, cognition disturbances, anhedonia, alcoholism etc.). Additionally, this model facilitates the screening of drugs for therapeutic properties, preventive properties and efficiency under simulated clinical conditions. This approach can reveal the action of drugs at different stages of disease development. It is proposed that this pharmacological approach can be applied for the screening of various novel psychotropic drugs.

Keywords: Sensory contact model, psychotropic drugs, screening

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