Abstract
The potential for carotenoids to modulate chronic diseases related to smoke is currently under investigation and renewed interest has been placed on achieving a better understanding of the mechanism(s) of action of carotenoids in smoke-exposed biological systems. Available data currently show that, while carotenoids alone are not harmful, their interaction with smoke may shift from beneficial to detrimental depending on the dose, the type of carotenoid as well as the biological environment in which they act. Several mechanisms have been proposed to explain such a shift. They include: (i) changes in cell oxidative status, which tips the β-carotene antioxidantprooxidant balance toward a prooxidant status; (ii) modulation of the levels of key proteins involved in the regulation of cell proliferation and apoptosis; (iii) reduction of retinoic acid signal pathway which down-regulates the RARβ expression and up-regulates AP-1; (iv) interference with absorption of other nutrients at better antioxidant profile; (v) formation of specific carotenoid oxidation products. This review summarizes the available evidences in cultured cells, animal models and humans for a modulatory action of carotenoids on the dangerous effects of smoke and focuses on the main molecular pathways involved in this process.
Keywords: Carotenoids, carotenoid oxidation products and metabolites, cigarette smoke, tar, redox status, DNA adducts, cytochrome P-450, cell signalling
Current Medicinal Chemistry
Title: Interplay of Carotenoids with Cigarette Smoking: Implications in Lung Cancer
Volume: 15 Issue: 9
Author(s): Paola Palozza, Rossella Simone and Maria Cristina Mele
Affiliation:
Keywords: Carotenoids, carotenoid oxidation products and metabolites, cigarette smoke, tar, redox status, DNA adducts, cytochrome P-450, cell signalling
Abstract: The potential for carotenoids to modulate chronic diseases related to smoke is currently under investigation and renewed interest has been placed on achieving a better understanding of the mechanism(s) of action of carotenoids in smoke-exposed biological systems. Available data currently show that, while carotenoids alone are not harmful, their interaction with smoke may shift from beneficial to detrimental depending on the dose, the type of carotenoid as well as the biological environment in which they act. Several mechanisms have been proposed to explain such a shift. They include: (i) changes in cell oxidative status, which tips the β-carotene antioxidantprooxidant balance toward a prooxidant status; (ii) modulation of the levels of key proteins involved in the regulation of cell proliferation and apoptosis; (iii) reduction of retinoic acid signal pathway which down-regulates the RARβ expression and up-regulates AP-1; (iv) interference with absorption of other nutrients at better antioxidant profile; (v) formation of specific carotenoid oxidation products. This review summarizes the available evidences in cultured cells, animal models and humans for a modulatory action of carotenoids on the dangerous effects of smoke and focuses on the main molecular pathways involved in this process.
Export Options
About this article
Cite this article as:
Palozza Paola, Simone Rossella and Mele Cristina Maria, Interplay of Carotenoids with Cigarette Smoking: Implications in Lung Cancer, Current Medicinal Chemistry 2008; 15 (9) . https://dx.doi.org/10.2174/092986708783955400
DOI https://dx.doi.org/10.2174/092986708783955400 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Growth Factors as Therapeutics for Diabetic Neuropathy
Current Drug Targets Nanosponges Encapsulated Phytochemicals for Targeting Cancer: A Review
Current Drug Targets Cruciferous Plants: Phytochemical Toxicity Versus Cancer Chemoprotection
Mini-Reviews in Medicinal Chemistry Cytochromes P450 in the Bioactivation of Chemicals
Current Topics in Medicinal Chemistry Stem Cell Based Preclinical Drug Development and Toxicity Prediction
Current Pharmaceutical Design Cancer-Related Fatigue: Still an Enigma to be Solved Quickly
Reviews on Recent Clinical Trials Volatile Disease Biomarkers in Breath: A Critique
Current Pharmaceutical Biotechnology Role of Tyrosine Kinase Inhibitors in Lung Cancer
Anti-Cancer Agents in Medicinal Chemistry Synthetic Approaches to Various Class of Topoisomerase II Inhibitors
Mini-Reviews in Organic Chemistry Synthesis and Biological Evaluations of Cytotoxic and Antiangiogenic Triterpenoids-Jacaranone Conjugates
Medicinal Chemistry Genomics and Pharmacogenomics in the Management of Breast Cancer
Current Pharmacogenomics and Personalized Medicine Camptothecin: Therapeutic Potential and Biotechnology
Current Pharmaceutical Biotechnology A Bioinformatics Pipeline for Cancer Epigenetics
Current Bioinformatics Physiological and Pathophysiological Functions of SIRT1
Mini-Reviews in Medicinal Chemistry Stem Cell Transplantation for Hematological Malignancies: Prospects for Personalized Medicine and Co-therapy with Mesenchymal Stem Cells
Current Pharmacogenomics and Personalized Medicine Immunotherapy for Non-Small Cell Lung Cancer - Finally a Hint of Hope
Reviews on Recent Clinical Trials Biotechnological Production of Taxol and Related Taxoids: Current State and Prospects
Anti-Cancer Agents in Medicinal Chemistry Pharmacophore Modeling for Antitargets
Current Topics in Medicinal Chemistry EGFR Expression Correlates with Maximum Standardized Uptake Value of 18F- fluorodeoxyglucose-PET in Squamous Cell Lung Carcinoma
Current Radiopharmaceuticals Optimizing Gene Silencing Strategies for Pancreatic Cancer
Current Cancer Therapy Reviews