Abstract
Despite its clinical importance, the mechanism of preeclampsia is unclear; however, many believe placental pathology might be related to maternal systemic disease. If this is true, a factor which mediates information from the placenta to the maternal circulation can be hypothesized. Among a variety of such reported factors, soluble fms-like tyrosine kinase-1 (sFlt1) will be the focus of this review. The hypoxic placenta, which is commonly found in preeclampsia, produces sFlt1; furthermore, animal experiments suggest its overexpression leads to preeclampsia-like symptoms.
Keywords: Preeclampsia, sFlt-1, PlGF, VEGF, hypoxia
Current Medicinal Chemistry
Title: A Possible Placental Factor for Preeclampsia: sFlt-1
Volume: 15 Issue: 7
Author(s): Naoko Kita and Junji Mitsushita
Affiliation:
Keywords: Preeclampsia, sFlt-1, PlGF, VEGF, hypoxia
Abstract: Despite its clinical importance, the mechanism of preeclampsia is unclear; however, many believe placental pathology might be related to maternal systemic disease. If this is true, a factor which mediates information from the placenta to the maternal circulation can be hypothesized. Among a variety of such reported factors, soluble fms-like tyrosine kinase-1 (sFlt1) will be the focus of this review. The hypoxic placenta, which is commonly found in preeclampsia, produces sFlt1; furthermore, animal experiments suggest its overexpression leads to preeclampsia-like symptoms.
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Cite this article as:
Kita Naoko and Mitsushita Junji, A Possible Placental Factor for Preeclampsia: sFlt-1, Current Medicinal Chemistry 2008; 15 (7) . https://dx.doi.org/10.2174/092986708783885309
DOI https://dx.doi.org/10.2174/092986708783885309 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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