Abstract
Proteomics has unraveled important questions in the biology of cardiovascular disease and holds even greater promise for the development of novel diagnostic and prognostic biomarkers. This approach may establish early detection strategies, and monitor responses to therapies. Technological advances (most notably blue native polyacrylamide gel electrophoresis, electrospray ionization, matrix- assisted laser desorption/ionization (MALDI), analysis of MALDI-derived peptides in Time-of-Flight (TOF) analyzers, and multidimensional protein identification technology (MudPIT) and bioinformatics for data handling and interpretation allow a large-scale identification of peptide sequence and post-translational modifications. Moreover, combination of proteomic biomarkers with clinical phenotype, metabolite changes, and genetic haplotype information is promising for the physician assessment of individual cardiovascular risk profile.
Keywords: mass spectrometry, two-dimensional gel electrophoresis, cardiovascular disease, Proteomics
Current Medicinal Chemistry
Title: Proteomics and Cardiovascular Disease: An Update
Volume: 15 Issue: 6
Author(s): Alfonso Giovane, Francesco Paolo Mancini, Claudio Napoli and Maria Luisa Balestrieri
Affiliation:
Keywords: mass spectrometry, two-dimensional gel electrophoresis, cardiovascular disease, Proteomics
Abstract: Proteomics has unraveled important questions in the biology of cardiovascular disease and holds even greater promise for the development of novel diagnostic and prognostic biomarkers. This approach may establish early detection strategies, and monitor responses to therapies. Technological advances (most notably blue native polyacrylamide gel electrophoresis, electrospray ionization, matrix- assisted laser desorption/ionization (MALDI), analysis of MALDI-derived peptides in Time-of-Flight (TOF) analyzers, and multidimensional protein identification technology (MudPIT) and bioinformatics for data handling and interpretation allow a large-scale identification of peptide sequence and post-translational modifications. Moreover, combination of proteomic biomarkers with clinical phenotype, metabolite changes, and genetic haplotype information is promising for the physician assessment of individual cardiovascular risk profile.
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Cite this article as:
Giovane Alfonso, Mancini Paolo Francesco, Napoli Claudio and Balestrieri Luisa Maria, Proteomics and Cardiovascular Disease: An Update, Current Medicinal Chemistry 2008; 15 (6) . https://dx.doi.org/10.2174/092986708783769713
DOI https://dx.doi.org/10.2174/092986708783769713 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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