Abstract
The goal of treatment in allergic rhinitis (AR) is to provide effective prevention of or relief from allergic rhinitis symptoms without adversely affecting daily activities or cognitive performance. Effective treatment of allergic rhinitis usually requires an integrated regimen that combines allergen avoidance measures, pharmacotherapy and possible specific- allergen immunotherapy. Oral corticosteroids are very effective but can have unwanted systemic effects. Over the past decade, intranasal corticosteroids have been shown to be the most effective form of pharmacologic treatment for allergic rhinitis. The newer nasal corticosteroids (NCS), offers significant advantages to the patient with AR. They are superior to both antihistamines and cromones and provide topical drug delivery that targets the actions of the drug molecules to the nasal mucosa to minimize the potential for systemic side effects. However, some clinicians remain reluctant to prescribe NCS for children because of their concern for systemic effects, including suppression of growth, of bone metabolism, and of the hypothalamic-pituitary-adrenal (HPA) axis.
Keywords: Allergic rhinitis, pharmacodynamics and pharmacokinetics, nasal corticosteroid, systemic corticosteroids, adverse effects
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: The Role of Corticosteroids in Allergic Rhinitis Treatment
Volume: 7 Issue: 1
Author(s): Murat Enoz
Affiliation:
Keywords: Allergic rhinitis, pharmacodynamics and pharmacokinetics, nasal corticosteroid, systemic corticosteroids, adverse effects
Abstract: The goal of treatment in allergic rhinitis (AR) is to provide effective prevention of or relief from allergic rhinitis symptoms without adversely affecting daily activities or cognitive performance. Effective treatment of allergic rhinitis usually requires an integrated regimen that combines allergen avoidance measures, pharmacotherapy and possible specific- allergen immunotherapy. Oral corticosteroids are very effective but can have unwanted systemic effects. Over the past decade, intranasal corticosteroids have been shown to be the most effective form of pharmacologic treatment for allergic rhinitis. The newer nasal corticosteroids (NCS), offers significant advantages to the patient with AR. They are superior to both antihistamines and cromones and provide topical drug delivery that targets the actions of the drug molecules to the nasal mucosa to minimize the potential for systemic side effects. However, some clinicians remain reluctant to prescribe NCS for children because of their concern for systemic effects, including suppression of growth, of bone metabolism, and of the hypothalamic-pituitary-adrenal (HPA) axis.
Export Options
About this article
Cite this article as:
Enoz Murat, The Role of Corticosteroids in Allergic Rhinitis Treatment, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2008; 7 (1) . https://dx.doi.org/10.2174/187152308783769140
DOI https://dx.doi.org/10.2174/187152308783769140 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
“Legal Highs” – New Players in the Old Drama
Current Drug Abuse Reviews Statin Treatment and the Natural History of Atherosclerotic-Related Diseases: Pathogenic Mechanisms and the Risk-Benefit Profile
Current Pharmaceutical Design NGS of microRNAs Involved in Cardioprotection Induced by Sevoflurane Compared to Propofol in Myocardial Revascularization Surgery: The ACDHUVV-16 Clinical Trial
Current Medicinal Chemistry The Effect of Chronic Co-Administration of Morphine and Verapamil on Isoproterenol-Induced Heart Injury
Cardiovascular & Hematological Agents in Medicinal Chemistry The Prevalence of the Classical and Non-Classical Cardiovascular Risk Factors in Multiple Sclerosis Patients
CNS & Neurological Disorders - Drug Targets Effects of PPARγ Agonists against Vascular and Renal Dysfunction
Current Molecular Pharmacology Lectin-Like Oxidized Low Density Lipoprotein Receptor 1 (LOX-1) in Atherogenesis: A Brief Review
Current Medicinal Chemistry HGF as Angiogenic Factor and Therapeutic Approach
Current Signal Transduction Therapy Patent Selections
Recent Patents on Biotechnology Therapy and Further Development of Anti-Leishmanial Drugs
Current Drug Therapy Injectable Drug-Loaded Nanocarriers for Lung Cancer Treatments
Current Pharmaceutical Design The Central Sympathetic Nervous System: A New Target for Cardioprotective Drugs
Drug Design Reviews - Online (Discontinued) Renal Development: A Complex Process Dependent on Inductive Interaction
Current Pediatric Reviews Physical Activity and Urinary Incontinence in Older Adults: A Community-Based Study
Current Aging Science Statins in Diabetes Mellitus
Current Pharmaceutical Design To Bleed or Not to Bleed: That is the Question. The Side Effects of Apixaban
Current Drug Targets The Role of Melanin to Dissociate Oxygen from Water to Treat Retinopathy of Prematurity
Central Nervous System Agents in Medicinal Chemistry Mechanisms of Neurodegeration in Type 2 Diabetes and the Neuroprotective Potential of Dipeptidyl Peptidase 4 Inhibitors
Current Medicinal Chemistry Pleiotropic Effects of Omega-3 Fatty Acids
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Advances in Sickle Cell Disease Treatments
Current Medicinal Chemistry