Abstract
Chronic pain is a highly prevalent condition that impacts adversely on individual quality of life, imposes substantial costs on the healthcare system and a considerable burden on society. Advances in the understanding of pain mechanisms have opened the way for the development of new treatment strategies. The continuous delivery of short-lived potent bioactive molecules to sensory nerves, spinal cord or meninges - achieved by directed gene transfer - offers the possibility to selectively interrupt nociceptive neurotransmission or to interfere with the plastic changes in the nervous system underlying the development or persistence of chronic pain. In this review we describe advances in the use of nonviral and viral vector-based gene transfer for the treatment of pain, with a special focus on the use of recombinant nonreplicating herpes simplex virus-based vectors and the prospects for clinical trials.
Keywords: Pain, enkephalin, endomorphin, gamma aminobutyric acid, cytokines, trophic factors, RNA interference, herpes simplex virus
Current Gene Therapy
Title: Applications of Gene Therapy to the Treatment of Chronic Pain
Volume: 8 Issue: 1
Author(s): Marina Mata, Shuanglin Hao and David J. Fink
Affiliation:
Keywords: Pain, enkephalin, endomorphin, gamma aminobutyric acid, cytokines, trophic factors, RNA interference, herpes simplex virus
Abstract: Chronic pain is a highly prevalent condition that impacts adversely on individual quality of life, imposes substantial costs on the healthcare system and a considerable burden on society. Advances in the understanding of pain mechanisms have opened the way for the development of new treatment strategies. The continuous delivery of short-lived potent bioactive molecules to sensory nerves, spinal cord or meninges - achieved by directed gene transfer - offers the possibility to selectively interrupt nociceptive neurotransmission or to interfere with the plastic changes in the nervous system underlying the development or persistence of chronic pain. In this review we describe advances in the use of nonviral and viral vector-based gene transfer for the treatment of pain, with a special focus on the use of recombinant nonreplicating herpes simplex virus-based vectors and the prospects for clinical trials.
Export Options
About this article
Cite this article as:
Mata Marina, Hao Shuanglin and Fink J. David, Applications of Gene Therapy to the Treatment of Chronic Pain, Current Gene Therapy 2008; 8 (1) . https://dx.doi.org/10.2174/156652308783688527
DOI https://dx.doi.org/10.2174/156652308783688527 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
Call for Papers in Thematic Issues
Programmed Cell Death Genes in Oncology: Pioneering Therapeutic and Diagnostic Frontiers (BMS-CGT-2024-HT-45)
Programmed Cell Death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes to the intricate landscape of cancer development and ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Ribosome Inactivating Proteins (RIPs) from Momordica charantia for Anti Viral Therapy
Current Molecular Medicine Topological Model for the Search of New Antibacterial Drugs. 158 Theoretical Candidates
Current Computer-Aided Drug Design Posaconazole: A New Antifungal Weapon
Reviews on Recent Clinical Trials Can Apolipoproteins and Complement Factors be Biomarkers of Alzheimer’s Disease?
Current Alzheimer Research NK-1 Receptor Antagonists: A New Generation of Anticancer Drugs
Mini-Reviews in Medicinal Chemistry Production and Application of Bacteriophage and Bacteriophage-Encoded Lysins
Recent Patents on Biotechnology Neuroimmune Crosstalk in CNS Disorders: The Histamine Connection
Current Pharmaceutical Design Burkholderia mallei and Burkholderia pseudomallei: The Causative Micro-organisms of Glanders and Melioidosis
Recent Patents on Anti-Infective Drug Discovery Activation of Latent HIV-1 Expression by Protein Kinase C Agonists. A Novel Therapeutic Approach to Eradicate HIV-1 Reservoirs
Current Drug Targets Mass Spectrometry in the Study of Hemoglobin: from Covalent Structure to Higher Order Assembly
Current Organic Chemistry Toll-Like Receptors and Human Disease: Lessons from Single Nucleotide Polymorphisms
Current Genomics Advances in Metabonomics on Infectious Diseases
Current Metabolomics Mutant Epidermal Growth Factor Receptors as Targets for Cancer Therapy
Current Cancer Drug Targets Role of miRNAs in Cancer Diagnostics and Therapy: A Recent Update
Current Pharmaceutical Design Association Between Seizures and Diabetes Mellitus: A Comprehensive Review of Literature
Current Diabetes Reviews Recent Advances in the Discovery of Novel Anti-Herpetic Agents from Chinese Herbal Medicines
Current Organic Chemistry A Review on Nuclear Imaging as a Promising Modality for Efficient Diagnosis of Tuberculosis
Current Medical Imaging Preclinical Models of Multiple Sclerosis: Advantages and Limitations Towards Better Therapies
Current Medicinal Chemistry Wzy-Dependent Bacterial Capsules as Potential Drug Targets
Current Drug Targets Drug Targeting Systems for Cancer Therapy: Nanotechnological Approach
Mini-Reviews in Medicinal Chemistry