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Current Genomics

Editor-in-Chief

ISSN (Print): 1389-2029
ISSN (Online): 1875-5488

Incomplete Coverage of Candidate Genes: A Poorly Considered Bias

Author(s): Alessandro Serretti, Antonio Drago and Diana De Ronchi

Volume 8, Issue 7, 2007

Page: [476 - 483] Pages: 8

DOI: 10.2174/138920207783591681

Price: $65

Abstract

Current genetic investigations are performed both on the basis of a rational and biologically based choice of candidate genes and through genome wide scans. Nonetheless, lack of replication is a common problem in psychiatric genetics as well as in other genetic fields. There are a number of reasons for this inconsistency, among them a well known but poorly considered issue is gene coverage. The aim of the present paper is to focus on this well known and defectively deemed bias, especially when a candidate gene approach is chosen. The rational and the technical feasibility of this proposal are discussed as well as a survey of current investigations. The known consistent methodology to fix this bias is also discussed.

Keywords: Candidate genes, association studies, psychiatry genetics, methodology

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