Generic placeholder image

Current Genomics

Editor-in-Chief

ISSN (Print): 1389-2029
ISSN (Online): 1875-5488

Myostatin in the Pathophysiology of Skeletal Muscle

Author(s): Anne Bonnieu, Gilles Carnac and Barbara Vernus

Volume 8, Issue 7, 2007

Page: [415 - 422] Pages: 8

DOI: 10.2174/138920207783591672

Price: $65

Abstract

Myostatin is an endogenous, negative regulator of muscle growth determining both muscle fiber number and size. The myostatin pathway is conserved across diverse species ranging from zebrafish to humans. Experimental models of muscle growth and regeneration have implicated myostatin as an important mediator of catabolic pathways in muscle cells. Inhibition of this pathway has emerged as a promising therapy for muscle wasting. Here we discuss the recent developments and the controversies in myostatin research, focusing on the molecular and cellular mechanisms underlying the actions of myostatin on skeletal muscle and the potential therapeutic role of myostatin on muscle-related disorders.

Keywords: p38 MAPK, myostatin, satellite cells, extra-cellular matrix, muscle regeneration

Next »

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy