Abstract
Several decades of investigation concerning the cause and cure of cancer have revealed major discrepancies in the response of different cancer types towards a particular therapy and therefore a need for more effective approaches has been conceived. It is known that cancer development irrespective of its origin occurs due to the compromises that normal cells make in critical pathways, thereby allowing to transform into a tumor. It is thus conceivable that the most effective cancer therapy requires multiple targeting of molecular alterations responsible for malignant transformation. In this context, the development of combinational therapies aimed at multi-cornered attack on cancer cells is of particular significance. The present article is a brief review of the novel trends emerging in cancer therapeutics with special emphasis on epigenetic therapy, cancer stem cell therapy, modern radiotherapy, target based cancer therapy and polyphenol therapy.
Keywords: Cancer, epigenetic, therapeutics, radiotherapy, cancer stem cells, polyphenols
Current Cancer Therapy Reviews
Title: Cancer Therapeutics: Emerging Targets and Trends
Volume: 4 Issue: 1
Author(s): Mohd. Fahad Ullah
Affiliation:
Keywords: Cancer, epigenetic, therapeutics, radiotherapy, cancer stem cells, polyphenols
Abstract: Several decades of investigation concerning the cause and cure of cancer have revealed major discrepancies in the response of different cancer types towards a particular therapy and therefore a need for more effective approaches has been conceived. It is known that cancer development irrespective of its origin occurs due to the compromises that normal cells make in critical pathways, thereby allowing to transform into a tumor. It is thus conceivable that the most effective cancer therapy requires multiple targeting of molecular alterations responsible for malignant transformation. In this context, the development of combinational therapies aimed at multi-cornered attack on cancer cells is of particular significance. The present article is a brief review of the novel trends emerging in cancer therapeutics with special emphasis on epigenetic therapy, cancer stem cell therapy, modern radiotherapy, target based cancer therapy and polyphenol therapy.
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Ullah Fahad Mohd., Cancer Therapeutics: Emerging Targets and Trends, Current Cancer Therapy Reviews 2008; 4 (1) . https://dx.doi.org/10.2174/157339408783565493
DOI https://dx.doi.org/10.2174/157339408783565493 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
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Current progress in Protein Degradation and Cancer Therapy
argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
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