Abstract
Integrins are αβ heterodimeric receptors that connect the extracellular environment with intracellular signaling events. Integrins are important for normal development and function, but are also involved in the pathogenesis of diseases including cancer, autoimmunity and heart disease. We will review the present data on a family of integrins, the collagen receptors that include the α1β1, α2β1, α10β1 and αα11β1 integrins. We will describe the knowledge gained from genetic deletion of each integrin in animal models. Mice lacking any single collagen receptor display no overt defect. However, studies using the α1β1 and α2β1 integrin-deficient mice indicate that these receptors play an important role in innate immunity, inflammation and autoimmunity. Finally, we will elucidate the interesting and sometimes overlapping roles for α1β1 and α2β1 integrins in disease and will propose potential stategies to therapeutically target these receptors to alleviate or treat disease.
Keywords: Integrins, collagen receptors, innate immunity, autoimmunity
Current Drug Targets
Title: Collagen Receptor Integrins: Rising to the Challenge
Volume: 9 Issue: 2
Author(s): M. M. Zutter and K. D. McCall-Culbreath
Affiliation:
Keywords: Integrins, collagen receptors, innate immunity, autoimmunity
Abstract: Integrins are αβ heterodimeric receptors that connect the extracellular environment with intracellular signaling events. Integrins are important for normal development and function, but are also involved in the pathogenesis of diseases including cancer, autoimmunity and heart disease. We will review the present data on a family of integrins, the collagen receptors that include the α1β1, α2β1, α10β1 and αα11β1 integrins. We will describe the knowledge gained from genetic deletion of each integrin in animal models. Mice lacking any single collagen receptor display no overt defect. However, studies using the α1β1 and α2β1 integrin-deficient mice indicate that these receptors play an important role in innate immunity, inflammation and autoimmunity. Finally, we will elucidate the interesting and sometimes overlapping roles for α1β1 and α2β1 integrins in disease and will propose potential stategies to therapeutically target these receptors to alleviate or treat disease.
Export Options
About this article
Cite this article as:
Zutter M. M. and McCall-Culbreath D. K., Collagen Receptor Integrins: Rising to the Challenge, Current Drug Targets 2008; 9 (2) . https://dx.doi.org/10.2174/138945008783502494
DOI https://dx.doi.org/10.2174/138945008783502494 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Update on the Evidence of Statin Treatment to Reduce Plaque Vulnerability
Drug Metabolism Letters The Potential Role of Thiamine (Vitamin B1) in Diabetic Complications
Current Diabetes Reviews The Role of microRNAs in Cardiovascular Disease
Current Medicinal Chemistry A Review on the Use of Statins and Tocotrienols, Individually or in Combination for the Treatment of Osteoporosis
Current Drug Targets HPLC-DAD-Q-TOF/MS-Based Screening and Analysis of the Multiple Absorbed Bioactive Components in Rat Serum after Oral Administration of Xiexin Tang
Current Pharmaceutical Analysis Role of Hyperglycaemia in Pathogenesis of Diabetic Cardiovascular Disease
Vascular Disease Prevention (Discontinued) Frailty of Older Age: The Role of the Endocrine - Immune Interaction
Current Pharmaceutical Design Sleep Apnea and Coronary Heart Disease: From Dusk Till Dawn and Further
Current Respiratory Medicine Reviews Cardiac Autonomic Nervous System in Heart Failure: Imaging Technique and Clinical Implications
Current Cardiology Reviews Enzymatic Processing of <i>Omega</i> 3 Long Chain Polyunsaturated Fatty Acid Oils
Current Nutrition & Food Science The Biology and Therapeutic Potential of the DDAH/ADMA Pathway
Current Pharmaceutical Design Female Infertility and Cardiovascular Risk - A Hype or an Underestimated Reality?
Current Pharmaceutical Design Retraction Note: Phytochemicals from Plants to Combat Cardiovascular Disease
Current Medicinal Chemistry Cardiovascular Risk Factors in Chronic Inflammatory Rheumatic Diseases: Modern Assessment and Diagnosis
Current Vascular Pharmacology Mass Spectrometry Data Analysis in the Proteomics Era
Current Bioinformatics Randomized Clinical Stroke Trials in 2006
Current Vascular Pharmacology The Role of Angiogenesis in Coronary Artery Disease: A Double-Edged Sword: Intraplaque Angiogenesis in Physiopathology and Therapeutic Angiogenesis for Treatment
Current Pharmaceutical Design Periodontal Disease and Potential Association with Systemic Diseases and Conditions (Mini-review)
Applied Clinical Research, Clinical Trials and Regulatory Affairs Season of Birth Effects on Reproduction in Women
Current Women`s Health Reviews Arterial Ischemic Stroke in Neonates and Children: Review and Current Issues
Current Pediatric Reviews