Abstract
Opioids remain an important cornerstone and the most effective mainstay analgesics for acute and terminal cancer pain treatments. Effective analgesia is obtained in the majority of cancer pain patients with the application of fairly straightforward rational treatment algorithms using opioids as the main therapy. A major barrier to be overcome, however, is that chronic pain is often not viewed as a physical illness worthy of treatment. Many studies demonstrating that specific changes occur in the peripheral and central nervous systems of patients with chronic pain provide the rationale for changing the approaches to chronic pain management and instituting more aggressive and comprehensive treatment. This review describes the role of opioids in the treatment of cancer pain, including a brief overview of cancer pain syndromes, essential aspects of opioid therapy, opioid pharmacology, opioid rotation, properties of the individual opioids, and management of common side effects of opioids. As understanding of the pharmacology of this class of drugs becomes more sophisticated, clinicians may anticipate dosage-limiting adverse effects and variations in individual response.
Keywords: Chronic pain, breakthrough pain, degenerative joint diseases, fibromyalgia, visceral diseases, cancer, opioids, hydromorphone, hydrocodone, oxycodone
Current Drug Therapy
Title: Review of Rational Approaches to the Treatment of Pain Management-Role forOpioids Therapies
Volume: 3 Issue: 1
Author(s): Pankaj Modi
Affiliation:
Keywords: Chronic pain, breakthrough pain, degenerative joint diseases, fibromyalgia, visceral diseases, cancer, opioids, hydromorphone, hydrocodone, oxycodone
Abstract: Opioids remain an important cornerstone and the most effective mainstay analgesics for acute and terminal cancer pain treatments. Effective analgesia is obtained in the majority of cancer pain patients with the application of fairly straightforward rational treatment algorithms using opioids as the main therapy. A major barrier to be overcome, however, is that chronic pain is often not viewed as a physical illness worthy of treatment. Many studies demonstrating that specific changes occur in the peripheral and central nervous systems of patients with chronic pain provide the rationale for changing the approaches to chronic pain management and instituting more aggressive and comprehensive treatment. This review describes the role of opioids in the treatment of cancer pain, including a brief overview of cancer pain syndromes, essential aspects of opioid therapy, opioid pharmacology, opioid rotation, properties of the individual opioids, and management of common side effects of opioids. As understanding of the pharmacology of this class of drugs becomes more sophisticated, clinicians may anticipate dosage-limiting adverse effects and variations in individual response.
Export Options
About this article
Cite this article as:
Modi Pankaj, Review of Rational Approaches to the Treatment of Pain Management-Role forOpioids Therapies, Current Drug Therapy 2008; 3 (1) . https://dx.doi.org/10.2174/157488508783331199
DOI https://dx.doi.org/10.2174/157488508783331199 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Role of Endothelial Progenitor Cell Mobilization After Percutaneous Angioplasty Procedure
Current Pharmaceutical Design Does Daily Dialysis Improve Hypertension in Chronic Haemodialysis Patients?
Current Hypertension Reviews Metabolism of Rhaponticin and Activities of its Metabolite, Rhapontigenin: A Review
Current Medicinal Chemistry Mediterranean Diet and the Metabolic Syndrome: The Role of Protein
Current Nutrition & Food Science Molecular Mechanisms of Neuronal Histamine and its Receptors in Obesity
Current Molecular Pharmacology Clinical Evidence of Herb-Drug Interactions: A Systematic Review by the Natural Standard Research Collaboration
Current Drug Metabolism Nutritional Antioxidants Mechanisms of Action, Analyses of Activities and Medical Applications
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Involvement of Coagulation and Hemostasis in Inflammatory Bowel Diseases
Current Vascular Pharmacology Emerging Advances in Nanomedicine as a Nanoscale Pharmacotherapy in Rheumatoid Arthritis: State of the Art
Current Topics in Medicinal Chemistry Selenium, an Ambivalent Factor in Diabetes? Established Facts, Recent Findings and Perspectives
Current Nutrition & Food Science Utility of Intrapartum Transabdominal Ultrasound for the Correct Placement of Vacuum during Assisted Delivery
Current Women`s Health Reviews Editorial from Guest Editor [Hot Topic:Vitamin D and Respiratory Health (Guest Editor: Adrian R. Martineau)]
Current Respiratory Medicine Reviews Expression and Role of the Calcium-Sensing Receptor in the Blood Vessel Wall
Current Pharmaceutical Biotechnology Microbial Interaction of Periodontopathic Bacterium Porphyromonas gingivalis and HIV-Possible Causal Link of Periodontal Diseases to AIDS Progression-
Current HIV Research Angiotensin 1-7 Promotes Cardiac Angiogenesis Following Infarction
Current Vascular Pharmacology Perspectives on New Synthetic Curcumin Analogs and their Potential Anticancer Properties
Current Pharmaceutical Design Racial Differences in Gray Matter Integrity by Diffusion Tensor in Black and White Octogenarians
Current Alzheimer Research Interventions Against Sarcopenia in Older Persons
Current Pharmaceutical Design MRI Abnormalities Associated with Mild Cognitive Impairments of Vascular (VMCI) Versus Neurodegenerative (NMCI) Types Prodromal for Vascular and Alzheimers Dementias
Current Alzheimer Research The Epidemiology of Cardiovascular Disease in Adults with Type 1 Diabetes
Current Diabetes Reviews