Abstract
This review focuses on recent efforts in glycoconjugate construction for the creation and evaluation of vaccines based on carbohydrate cancer-associated antigens. This therapeutic approach takes advantage from the known tendency of transformed cells to express selective carbohydrate motifs otherwise hidden in normal cells. The immunological response is elicited by the association in the same molecule a carbohydrate, as B-cell antigen, and a peptide, or an entire protein, as T-cell epitope. We will review on the synthesis and the immunological investigation of various glycoconjugates presenting tumor-associated carbohydrate antigens. Different approaches including the use of clustered glycoconjugates such as multiple antigenic glycopeptides (MAG), and glyconanoparticles as potential antitumour therapeutics will be considered.
Keywords: Glycopeptides, glyconanoparticles, tumour-associated carbohydrate antigens, glycoconjugates, anti-tumour vaccines
Anti-Cancer Agents in Medicinal Chemistry
Title: Glycoconjugates in Cancer Therapy
Volume: 8 Issue: 1
Author(s): Laura Cipolla, Francesco Peri and Cristina Airoldi
Affiliation:
Keywords: Glycopeptides, glyconanoparticles, tumour-associated carbohydrate antigens, glycoconjugates, anti-tumour vaccines
Abstract: This review focuses on recent efforts in glycoconjugate construction for the creation and evaluation of vaccines based on carbohydrate cancer-associated antigens. This therapeutic approach takes advantage from the known tendency of transformed cells to express selective carbohydrate motifs otherwise hidden in normal cells. The immunological response is elicited by the association in the same molecule a carbohydrate, as B-cell antigen, and a peptide, or an entire protein, as T-cell epitope. We will review on the synthesis and the immunological investigation of various glycoconjugates presenting tumor-associated carbohydrate antigens. Different approaches including the use of clustered glycoconjugates such as multiple antigenic glycopeptides (MAG), and glyconanoparticles as potential antitumour therapeutics will be considered.
Export Options
About this article
Cite this article as:
Cipolla Laura, Peri Francesco and Airoldi Cristina, Glycoconjugates in Cancer Therapy, Anti-Cancer Agents in Medicinal Chemistry 2008; 8 (1) . https://dx.doi.org/10.2174/187152008783330815
DOI https://dx.doi.org/10.2174/187152008783330815 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
Call for Papers in Thematic Issues
Induction of cell death in cancer cells by modulating telomerase activity using small molecule drugs
Telomeres are distinctive but short stretches present at the corners of chromosomes and aid in stabilizing chromosomal makeup. Resynthesis of telomeres supported by the activity of reverse transcriptase ribonucleoprotein complex telomerase. There is no any telomerase activity in human somatic cells, but the stem cells and germ cells undergone telomerase ...read more
Role of natural compounds as anti anti-cancer agents
Cancer is considered the leading cause of worldwide mortality, accounting for nearly 10 million deaths in 2022. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy remains an important approach in treatment o f several types of cancers, even though ...read more
Signaling and enzymatic modulators in cancer treatment
Cancer accounts for nearly 10 million deaths in 2022 and is considered the leading cause of worldwide mortality. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy, radiotherapy and surgery are the most important approach for the treatment of several ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
A Medicinal Chemist’s Perspective Towards Structure Activity Relationship of Heterocycle Based Anticancer Agents
Current Topics in Medicinal Chemistry Structure, Roles and Inhibitors of a Mitotic Protein Kinase Haspin
Current Medicinal Chemistry Vitamins and Cognition: A Nutrigenomics Perspective
Current Nutrition & Food Science Potential Benefits of Glitazones for Cancer and Vascular Disease
Current Drug Therapy Frontotemporal Dementia Caused by CHMP2B Mutations
Current Alzheimer Research Anti-Cancer/Anti-Tumor
Current Bioactive Compounds EZN-2208 (PEG-SN38), A 40 kDa Polyethylene Glycol (PEG) Conjugate, As an Anticancer Agent: Review of Preclinical and Clinical Data
Current Bioactive Compounds Encountering and Advancing Through Antiangiogenesis Therapy for Gliomas
Current Pharmaceutical Design Hedgehog Signaling and Urological Cancers
Current Drug Targets Structure – Function Relationships of Pre-Fibrillar Protein Assemblies in Alzheimers Disease and Related Disorders
Current Alzheimer Research Neurodevelopment in Schizophrenia: The Role of the Wnt Pathways
Current Neuropharmacology Peptides for In Vivo Target-Specific Cancer Imaging
Mini-Reviews in Medicinal Chemistry NPY Signalling Pathway in Bone Homeostasis: Y1 Receptor as a Potential Drug Target
Current Drug Targets Recent Advances of Metallocenes for Medicinal Chemistry
Mini-Reviews in Medicinal Chemistry Skeletal Muscle Cell Behavior After Physical Agent Treatments
Current Pharmaceutical Design From French Paradox to Cancer Treatment: Anti-cancer Activities and Mechanisms of Resveratrol
Anti-Cancer Agents in Medicinal Chemistry The Endocannabinoid System in Amyotrophic Lateral Sclerosis
Current Pharmaceutical Design A Review of Titanium Di Oxide Nanoparticles - Synthesis, Applications and Toxicity Concerns
Nanoscience & Nanotechnology-Asia Significance of Genome-Wide Analysis of Copy Number Alterations and UPD in Myelodysplastic Syndromes using Combined CGH – SNP Arrays
Current Medicinal Chemistry Low Doses Naltrexone: The Potential Benefit Effects for its Use in Patients with Cancer
Current Drug Research Reviews