Abstract
A summary of spectroscopic methods for structural and conformational elucidation of bioactive carbohydrates based on nuclear magnetic resonance (NMR) is described. The formation of carbohydrate-protein complexes is often the initial step of biological responses. Therefore, knowledge about the structural factors that stabilize the complex may be relevant and contribute to predict the structural/ conformational requirements of new drugs acting as agonists. Two examples of medical significance in the cancer research field are discussed (1) conformational studies of glycoconjugates related to antitumour vaccines (2) conformational analysis of glycosaminoglycans and the interaction heparin-fibroblast growth factor (FGF).
Keywords: Cancer, NMR, glycoconjugates, glycosaminoglycans
Anti-Cancer Agents in Medicinal Chemistry
Title: NMR Structural Studies of Oligosaccharides Related to Cancer Processes
Volume: 8 Issue: 1
Author(s): J. Jimenez-Barbero, M. D. Diaz and P. M. Nieto
Affiliation:
Keywords: Cancer, NMR, glycoconjugates, glycosaminoglycans
Abstract: A summary of spectroscopic methods for structural and conformational elucidation of bioactive carbohydrates based on nuclear magnetic resonance (NMR) is described. The formation of carbohydrate-protein complexes is often the initial step of biological responses. Therefore, knowledge about the structural factors that stabilize the complex may be relevant and contribute to predict the structural/ conformational requirements of new drugs acting as agonists. Two examples of medical significance in the cancer research field are discussed (1) conformational studies of glycoconjugates related to antitumour vaccines (2) conformational analysis of glycosaminoglycans and the interaction heparin-fibroblast growth factor (FGF).
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Cite this article as:
Jimenez-Barbero J., Diaz D. M. and Nieto M. P., NMR Structural Studies of Oligosaccharides Related to Cancer Processes, Anti-Cancer Agents in Medicinal Chemistry 2008; 8 (1) . https://dx.doi.org/10.2174/187152008783330879
DOI https://dx.doi.org/10.2174/187152008783330879 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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