Abstract
The advent of RNA interference (RNAi) based library screening approaches has sparked a surge in loss-of-function genetic screens. Several recent screens have aimed to identify novel regulators of cancer-related phenotypes. These employ various tumor cell types to model malignant cell functions and use different RNAi effector library approaches to reveal a cache of novel tumor regulators. This review surveys recent RNAi screens conducted in transformed human cells.
Keywords: RNA interference, genetic screen, cancer, therapeutic target
Current Pharmaceutical Biotechnology
Title: RNAi Screening for Therapeutic Targets in Human Malignancies
Volume: 8 Issue: 6
Author(s): David R. Micklem and James B. Lorens
Affiliation:
Keywords: RNA interference, genetic screen, cancer, therapeutic target
Abstract: The advent of RNA interference (RNAi) based library screening approaches has sparked a surge in loss-of-function genetic screens. Several recent screens have aimed to identify novel regulators of cancer-related phenotypes. These employ various tumor cell types to model malignant cell functions and use different RNAi effector library approaches to reveal a cache of novel tumor regulators. This review surveys recent RNAi screens conducted in transformed human cells.
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Cite this article as:
Micklem R. David and Lorens B. James, RNAi Screening for Therapeutic Targets in Human Malignancies, Current Pharmaceutical Biotechnology 2007; 8 (6) . https://dx.doi.org/10.2174/138920107783018426
DOI https://dx.doi.org/10.2174/138920107783018426 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
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