Abstract
Diabetes mellitus is a chronic metabolic disorder, characterized by glucose overproduction and glucose underutilization. Current therapy for T2DM includes drugs, like metformin, glitazones, sulphonyl ureas, etc. Extensive research has been carried out world wide on molecular targets for T2DM like PPARγ, PTP1B, DPP-IV, GSK-3, cannabinoid receptor, fructose-bisphosphatases, β3 adrenoceptor, etc. in the development of newer anti-diabetic agents. These therapeutic targets are quite important and most of them are suitable for in silico analysis. Hence, many molecular modeling and informatics studies like, molecular docking, pharmacophore mapping, 3DQSAR, virtual screening, quantum chemical studies, and pharmacoinformatics like bioinformatics and chemoinformatics studies have been performed on the drugs / leads / targets associated with T2DM. Several of these in silico efforts are exemplary studies; the methodologies adopted in these studies can be emulated in many other therapeutic areas. A review of the rational approaches reported in designing anti-diabetic agents is presented in this article.
Keywords: Molecular modeling, informatics, Diabetes mellitus, Dipeptidyl peptidase IV, Cannabinoid, β3-adrenoceptor, Glycogen synthase kinase-3, Protein tyrosine phosphatase-1B, Pyruvate dehydogenase kinase
Current Pharmaceutical Design
Title: Modeling and Informatics in Designing Anti-Diabetic Agents
Volume: 13 Issue: 34
Author(s): P. V. Bharatam, D. S. Patel, L. Adane, A. Mittal and S. Sundriyal
Affiliation:
Keywords: Molecular modeling, informatics, Diabetes mellitus, Dipeptidyl peptidase IV, Cannabinoid, β3-adrenoceptor, Glycogen synthase kinase-3, Protein tyrosine phosphatase-1B, Pyruvate dehydogenase kinase
Abstract: Diabetes mellitus is a chronic metabolic disorder, characterized by glucose overproduction and glucose underutilization. Current therapy for T2DM includes drugs, like metformin, glitazones, sulphonyl ureas, etc. Extensive research has been carried out world wide on molecular targets for T2DM like PPARγ, PTP1B, DPP-IV, GSK-3, cannabinoid receptor, fructose-bisphosphatases, β3 adrenoceptor, etc. in the development of newer anti-diabetic agents. These therapeutic targets are quite important and most of them are suitable for in silico analysis. Hence, many molecular modeling and informatics studies like, molecular docking, pharmacophore mapping, 3DQSAR, virtual screening, quantum chemical studies, and pharmacoinformatics like bioinformatics and chemoinformatics studies have been performed on the drugs / leads / targets associated with T2DM. Several of these in silico efforts are exemplary studies; the methodologies adopted in these studies can be emulated in many other therapeutic areas. A review of the rational approaches reported in designing anti-diabetic agents is presented in this article.
Export Options
About this article
Cite this article as:
Bharatam V. P., Patel S. D., Adane L., Mittal A. and Sundriyal S., Modeling and Informatics in Designing Anti-Diabetic Agents, Current Pharmaceutical Design 2007; 13 (34) . https://dx.doi.org/10.2174/138161207782794239
DOI https://dx.doi.org/10.2174/138161207782794239 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Endothelial Effects of Drugs Designed to Treat Erectile Dysfunction
Current Pharmaceutical Design Interaction Between Bone and Muscle in Older Persons with Mobility Limitations
Current Pharmaceutical Design Diagnosis, Treatment, and New Developments in Preeclampsia
Current Women`s Health Reviews Current Concepts in the Management of Diabetic Polyneuropathy
Current Diabetes Reviews Current Pharmacological Treatment of Nonalcoholic Fatty Liver
Current Medicinal Chemistry Nitric Oxide and Oral Diseases: Can We Talk About It?
Cardiovascular & Hematological Agents in Medicinal Chemistry Conjugative Post-Translational Modifications for Pharmacological Improvement of Therapeutic Proteins
Current Proteomics Drug Development from Natural Resource: A Systematic Approach
Mini-Reviews in Medicinal Chemistry Update on Statins: Hope for Osteoporotic Fracture Healing Treatment
Current Drug Targets A High Burden of Ischemic Stroke in Regions of Eastern/Central Europe is Largely Due to Modifiable Risk Factors
Current Neurovascular Research Anti-Aging Effect of Metformin: A Molecular and Therapeutical Perspective
Current Pharmaceutical Design Impact of Diabetes on Cardiac and Vascular Disease: Role of Calcium Signaling
Current Medicinal Chemistry Acrylamide Induced Toxicity and the Propensity of Phytochemicals in Amelioration: A Review
Central Nervous System Agents in Medicinal Chemistry Diabetes Mellitus as a Risk Factor for Cancer: Stress or Viral Etiology?
Infectious Disorders - Drug Targets Use of Double-source Computed Tomography for Evaluation of the Relationship Between Smoking and Coronary Plaques
Current Medical Imaging Genomic Linkage Between Alzheimer's Disease and Type 2 Diabetes
CNS & Neurological Disorders - Drug Targets Editorial [The Role of Arachidonic Acid in the Neuronal Development in Relation to Psychiatric Disorders]
Current Psychopharmacology Visceral and Subcutaneous Adiposity: Are Both Potential Therapeutic Targets for Tackling the Metabolic Syndrome?
Current Pharmaceutical Design New Perspectives in the Pharmacological Potential of Naringin in Medicine
Current Medicinal Chemistry Diet, Cardiometabolic Factors and Type-2 Diabetes Mellitus: The Role of Genetics
Current Diabetes Reviews