Abstract
Stroke is thought to be a multifactorial disease that is affected by several environmental factors and genetic variants. In 2002, a candidate locus for stroke (STRK1) was identified with a significant logarithm of odds (LOD) score at 5q12 in Caucasians, and in 2003, the PDE4D gene was subsequently identified as a susceptibility gene at this locus. Some investigators have recently examined whether polymorphisms in the PDE4D gene are associated with stroke in population studies. Some of these studies have reported the polymorphisms to be associated with a risk of stroke, while others have reported the exact opposite. These discrepancies have been attributed to racial differences or differences in methodologies and analyses. In 2006, a powerful method for isolating the susceptibility region at 5q12 was reported in a haplotype-based case-control study. In the present paper, we review both current issues and progress in the isolation of susceptibility genes for ischemic stroke, with particular emphasis on the PDE4D gene in the STRK1 region of 5q12.
Keywords: Stroke, cerebral infarction, PDE4D gene, case-control study, mutation, polymorphism
Current Medicinal Chemistry
Title: PDE4D Gene in the STRK1 Region on 5q12: Susceptibility Gene for Ischemic Stroke
Volume: 14 Issue: 30
Author(s): Tomohiro Nakayama, Satoshi Asai, Naoyuki Sato and Masayoshi Soma
Affiliation:
Keywords: Stroke, cerebral infarction, PDE4D gene, case-control study, mutation, polymorphism
Abstract: Stroke is thought to be a multifactorial disease that is affected by several environmental factors and genetic variants. In 2002, a candidate locus for stroke (STRK1) was identified with a significant logarithm of odds (LOD) score at 5q12 in Caucasians, and in 2003, the PDE4D gene was subsequently identified as a susceptibility gene at this locus. Some investigators have recently examined whether polymorphisms in the PDE4D gene are associated with stroke in population studies. Some of these studies have reported the polymorphisms to be associated with a risk of stroke, while others have reported the exact opposite. These discrepancies have been attributed to racial differences or differences in methodologies and analyses. In 2006, a powerful method for isolating the susceptibility region at 5q12 was reported in a haplotype-based case-control study. In the present paper, we review both current issues and progress in the isolation of susceptibility genes for ischemic stroke, with particular emphasis on the PDE4D gene in the STRK1 region of 5q12.
Export Options
About this article
Cite this article as:
Nakayama Tomohiro, Asai Satoshi, Sato Naoyuki and Soma Masayoshi, PDE4D Gene in the STRK1 Region on 5q12: Susceptibility Gene for Ischemic Stroke, Current Medicinal Chemistry 2007; 14 (30) . https://dx.doi.org/10.2174/092986707782793871
DOI https://dx.doi.org/10.2174/092986707782793871 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
Current advances in inherited cardiomyopathy
Describe in detail all novel advances in multimodality imaging related to inherited cardiomyopathy diagnosis and prognosis. Shed light to deeper phenotypic characterization. Acknowledge recent advances in genetics, genomics and precision medicineread more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Ultrasound Diagnosis of Soft Tissue Vascular Malformations and Tumours
Current Medical Imaging Syncope in a Child with Pulmonary Hypertension and Positive Gene Tests for Hereditary Hemorrhagic Telangiectasia and Long QT Syndrome
Cardiovascular & Hematological Agents in Medicinal Chemistry Persistent Pulmonary Hypertension of the Newborn: Therapeutical Approach
Mini-Reviews in Medicinal Chemistry Optical Imaging of Microvascular Morphology and Perfusion
Current Angiogenesis (Discontinued) Cerebral Amyloid Angiopathy-related Intracerebral Hemorrhage Score For Predicting Outcome
Current Neurovascular Research Cerebrospinal Fluid Flow Dynamics in Multiple Sclerosis Patients through Phase Contrast Magnetic Resonance Imaging
Current Neurovascular Research The Role of microRNA in Ischemic and Hemorrhagic Stroke
Current Drug Delivery Current Status of Renal Arterial Endovascular Interventions
Current Hypertension Reviews Dealing with the Substance Abuse Epidemic and Infective Endocarditis:Clinical, Immunologic and Pathogenetic Aspects
Current Vascular Pharmacology The Effect of Chemotherapy/Radiotherapy on Cancerous Pattern Recognition by NK Cells
Current Medicinal Chemistry Non-Surgical Treatment Options for Symptomatic Uterine Leiomyomas
Current Women`s Health Reviews Fluorescein Fluorescence Use in the Management of Intracranial Neoplastic and Vascular Lesions: A Review and Report of a New Technique
Current Drug Discovery Technologies New Vessel Formation in the Central Nervous System During Tumor Growth, Vascular Malformations, and Moyamoya
Current Neurovascular Research Basis for the Application of Analytical Models of the Bloch NMR Flow Equations for Functional Magnetic Resonance Imaging (fMRI): A Review
Recent Patents on Medical Imaging Selection and Evaluation of the Pediatric Epilepsy Surgical Candidates
Current Pediatric Reviews Cerebral Aneurysm Formation in Nitric Oxide Synthase-3 Knockout Mice
Current Neurovascular Research Trefoil Factor Family (TFF) Peptides and their Different Roles in the Mucosal Innate Immune Defense and More: An Update
Current Medicinal Chemistry Meet Our Section Editor
Central Nervous System Agents in Medicinal Chemistry Mesenchymal Stromal Cells from Umbilical Cord Blood
Current Stem Cell Research & Therapy Intracranial Aneurysms; In Need of Early Diagnostic and Treatment Using Bio- and Nanotechnology
Current Medicinal Chemistry