The Molecular Basis of Susceptibility to Infection in Liver Cirrhosis

Author(s): Norberto C. Chavez-Tapia, Aldo Torre-Delgadillo, Felix I. Tellez-Avila, Misael Uribe.

Journal Name: Current Medicinal Chemistry

Volume 14 , Issue 28 , 2007

Abstract:

There is much clinical evidence of a relationship between infectious disease and chronic liver disease. The consequences of this adverse association have been described and advances in the treatment and prophylaxis of infectious disease have had an important effect on the management of patients with chronic liver disease. The association between infectious disease and chronic liver disease involves altered cytokine production, cellular immunity, and vascular response. However, there is little information on the mechanisms underlying these phenomena. In this report, we review the mechanistic basis of this common association.

Keywords: Infections, cirrhosis, cytokine, vascular, susceptibility

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Article Details

VOLUME: 14
ISSUE: 28
Year: 2007
Page: [2954 - 2958]
Pages: 5
DOI: 10.2174/092986707782794041
Price: $58

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