Abstract
Drug delivery systems largely contribute to cancer therapy in terms of tumor targeting and controlled release of cargo molecules. While targeting of tumor “tissue” has been achieved using nanocarriers, delivery of cargo molecules into tumor cells is still challenging. Intracellular delivery of nanocarriers is an essential process to overcome multi-drug resistance and for the delivery of cargo molecules for both therapy and vaccine applications. Nanocarriers may gain access to the interior of target cells either non-specifically, as in adsorptive endocytosis, or specifically, as in receptor-mediated endocytosis. Once internalized, they must subsequently break free of their endosomal compartments in order to deliver their cargo into either the cytosol or nucleus. If the nucleus is the target, as in DNA delivery, the nanocarrier must then traffick to the perinuclear region and deliver the cargo into the nucleus, either by physically transporting DNA through the nuclear pore complex (NPC), or by releasing DNA at the door of the NPC, allowing free DNA to gain access. This review article includes both principles and mechanisms of intracellular delivery of nanocarriers, and gives a few examples of their application.
Keywords: Intracellular delivery, cancer therapy, liposomes, polymeric carriers, nanoparticles, mechanisms
Current Nanoscience
Title: Intracellular Delivery of Nanocarriers for Cancer Therapy
Volume: 3 Issue: 4
Author(s): Yah-el Har-el and Yoshinori Kato
Affiliation:
Keywords: Intracellular delivery, cancer therapy, liposomes, polymeric carriers, nanoparticles, mechanisms
Abstract: Drug delivery systems largely contribute to cancer therapy in terms of tumor targeting and controlled release of cargo molecules. While targeting of tumor “tissue” has been achieved using nanocarriers, delivery of cargo molecules into tumor cells is still challenging. Intracellular delivery of nanocarriers is an essential process to overcome multi-drug resistance and for the delivery of cargo molecules for both therapy and vaccine applications. Nanocarriers may gain access to the interior of target cells either non-specifically, as in adsorptive endocytosis, or specifically, as in receptor-mediated endocytosis. Once internalized, they must subsequently break free of their endosomal compartments in order to deliver their cargo into either the cytosol or nucleus. If the nucleus is the target, as in DNA delivery, the nanocarrier must then traffick to the perinuclear region and deliver the cargo into the nucleus, either by physically transporting DNA through the nuclear pore complex (NPC), or by releasing DNA at the door of the NPC, allowing free DNA to gain access. This review article includes both principles and mechanisms of intracellular delivery of nanocarriers, and gives a few examples of their application.
Export Options
About this article
Cite this article as:
Har-el Yah-el and Kato Yoshinori, Intracellular Delivery of Nanocarriers for Cancer Therapy, Current Nanoscience 2007; 3 (4) . https://dx.doi.org/10.2174/157341307782418612
DOI https://dx.doi.org/10.2174/157341307782418612 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Cu-mediated synthesis of 2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-ones as potential inhibitors of sirtuins
Letters in Drug Design & Discovery Tumor Angiogenesis: A Target for Renal Cell Carcinoma Therapy. Current Perspectives and Novel Strategies
Recent Patents on Biomarkers On the Synthesis and Anticancer Testing of α,β-Unsaturated Ketones as Analogs of Combretastatin-A4
Letters in Drug Design & Discovery Doxorubicin vs. ladirubicin: methods for improving osteosarcoma treatment
Mini-Reviews in Medicinal Chemistry The Interaction of Histone Deacetylase Inhibitors and DNA Methyltransferase Inhibitors in the Treatment of Human Cancer Cells
Current Medicinal Chemistry - Anti-Cancer Agents Cancer Stem Cells: A New Paradigm for Understanding Tumor Growth and Progression and Drug Resistance
Current Medicinal Chemistry Azidothymidine is Effective Against Human Multiple Myeloma: A New Use for an Old Drug?
Anti-Cancer Agents in Medicinal Chemistry Adiponectin: Merely a Bystander or the Missing Link to Cardiovascular Disease?
Current Topics in Medicinal Chemistry <i>In Silico</i> and <i>in Vitro</i> Evaluation of Deamidation Effects on the Stability of the Fusion Toxin DAB<sub>389</sub>IL-2
Current Proteomics Coronary CT Angiography in the Diagnosis of Coronary Artery Disease
Current Medical Imaging Targeting Apoptotic Pathways in Myocardial Infarction: Attenuated by Phytochemicals
Cardiovascular & Hematological Agents in Medicinal Chemistry Regulation of Autophagy by Sphingolipids
Anti-Cancer Agents in Medicinal Chemistry Role of Oxygen in Cancer: Looking Beyond Hypoxia
Anti-Cancer Agents in Medicinal Chemistry Ligand-Peroxidase Conjugates for Quantification of Receptor-Mediated Transport into Cells
Combinatorial Chemistry & High Throughput Screening IDO+ DCs and Signalling Pathways
Current Cancer Drug Targets Current Status and Future Directions of Nanoparticulate Strategy for Cancer Immunotherapy
Current Drug Metabolism The Pathobiology of Endothelin-1 in Vein Graft Disease: Are ETA Receptor Antagonists the Solution to Prevent Vein Graft Failure?
Current Vascular Pharmacology An Overview of Phytotherapeutic Approaches for the Treatment of Benign Prostatic Hyperplasia
Mini-Reviews in Medicinal Chemistry Melanogenesis Inhibitors: Strategies for Searching for and Evaluation of Active Compounds
Current Medicinal Chemistry RhoGEFs in Cell Motility: Novel Links Between Rgnef and Focal Adhesion Kinase
Current Molecular Medicine