Overview of Murine Atherosclerosis Series

Godfrey   S.   Getz

Abstract

This volume recognizes the critical and central role of the mouse in experimental atherosclerosis pathology. Atherosclerosis is a complex and chronic inflammation [1] in which multiple modulating factors may play a role. Its chronicity and complexity make it very difficult to study the detailed mechanisms of atherogenesis in unregulated human populations. The search for atherogenic mechanisms requires a model in which these mechanisms simulate those inferred in humans, and in which controlled experiments may be conducted in a reasonable timeframe and at manageable expense. The mouse recommends itself as a small animal model with a short life span in which atherosclerosis similar in character to human atherosclerosis may be induced under controlled conditions. With the development of genetic models of atherosclerosis the mouse has become a very accessible model, especially with the very large genetic data base about this species in relation to human biology that has become available [1].

Keywords: Lipid, HDL, lipoprotein, mouse strain, metabolism