Abstract
Peptide Nucleic Acids (PNA) invented ten years ago are emerging rapidly as useful molecules in DNA hybridization and antisense techniques. Although therapeutic drugs based on PNA are still not in sight, applications in diagnostics, in particular in situ hybridization and PCR based systems, are making rapid strides. The simple structure of PNA in combination with impressive DNA mimicking properties has already provided inspiration to many synthetic organic chemists for designing and preparing several derivatives and analogs towards improving their physico-chemical and biological properties. This review which is not intended to be exhaustive, is aimed at highlighting the current progress in the areas of PNA chemistry, structure, hybridization, and applications. The various chemical backbone modifications of PNA reported till date are summarized in the context of DNA hybridization properties
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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