Abstract
Genetic instability often leads to tumourogenesis. Genomic alterations such as deletions of a chromosome region containing a tumour suppresser gene or amplification of a region containing an oncogene have been frequently found to be associated with the initiation and the progression of cancer. Therefore identification of chromosomal regions amplified or deleted in tumour cells may reveal the presence of such genes. Amplification of 20q13 for instance is frequently observed in breast cancer cells. This region contains a gene encoding a protein kinase that belongs to the Aurora/Ipl1p-related kinase family involved in microtubule dependent mitotic events that control chromosome segregation. Deregulation of these kinases perturbs the ploidy of the cells. The human genome encodes at least three different kinases that have been found to be overexpressed in different tumour cells. But only the ectopic overexpression of the kinase encoded by the gene located at 20q13 is capable to transform cultured cells an d induce the apparition of tumours in nude mouse. In this manuscript we describe the function of the three human Aurora/Ipl1p-related kinases, and review the genomic alterations reported for the chromosome region where the kinase genes localise. But we first discuss the impact of the human genome sequence project for the identification of new kinases in the context of cancer research.
Keywords: Aurora, Ipl1p Related Kinases, CDNA microarrays, Cellular apoptosis susceptibility, HsAIRK1, Xenopus laevis, HsAIRK2, HsAIRK3
Current Genomics
Title: Human Aurora / Ipl1p Related Kinases
Volume: 1 Issue: 3
Author(s): P. Sanseau, M. Bernard, Y. Arlot-Bonnemains and C Prigent
Affiliation:
Keywords: Aurora, Ipl1p Related Kinases, CDNA microarrays, Cellular apoptosis susceptibility, HsAIRK1, Xenopus laevis, HsAIRK2, HsAIRK3
Abstract: Genetic instability often leads to tumourogenesis. Genomic alterations such as deletions of a chromosome region containing a tumour suppresser gene or amplification of a region containing an oncogene have been frequently found to be associated with the initiation and the progression of cancer. Therefore identification of chromosomal regions amplified or deleted in tumour cells may reveal the presence of such genes. Amplification of 20q13 for instance is frequently observed in breast cancer cells. This region contains a gene encoding a protein kinase that belongs to the Aurora/Ipl1p-related kinase family involved in microtubule dependent mitotic events that control chromosome segregation. Deregulation of these kinases perturbs the ploidy of the cells. The human genome encodes at least three different kinases that have been found to be overexpressed in different tumour cells. But only the ectopic overexpression of the kinase encoded by the gene located at 20q13 is capable to transform cultured cells an d induce the apparition of tumours in nude mouse. In this manuscript we describe the function of the three human Aurora/Ipl1p-related kinases, and review the genomic alterations reported for the chromosome region where the kinase genes localise. But we first discuss the impact of the human genome sequence project for the identification of new kinases in the context of cancer research.
Export Options
About this article
Cite this article as:
Sanseau P., Bernard M., Arlot-Bonnemains Y. and Prigent C, Human Aurora / Ipl1p Related Kinases, Current Genomics 2000; 1 (3) . https://dx.doi.org/10.2174/1389202003351355
DOI https://dx.doi.org/10.2174/1389202003351355 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Advanced AI Techniques in Big Genomic Data Analysis
The thematic issue on "Advanced AI Techniques in Big Genomic Data Analysis" aims to explore the cutting-edge methodologies and applications of artificial intelligence (AI) in the realm of genomic research, where vast amounts of data pose both challenges and opportunities. This issue will cover a broad spectrum of AI-driven strategies, ...read more
Advanced Computational Algorithms and Artificial Intelligence in Clinical Pharmacogenomics
In the era of personalized medicine, understanding the relationship between genetics and drug response is crucial. This issue delves into innovative methodologies, leveraging deep computational analysis and artificial intelligence, to enhance the field of Clinical Pharmacogenomics. The interdisciplinary approach harnesses the power of advanced high-throughput genotyping technologies, sophisticated computational analysis, ...read more
Applications of Single-cell Sequencing Technology in Reproductive Medicine
Single cell sequencing (SCS) technology utilizes individual cells' genetic material to sequence their genome, transcriptome, and epigenetics at the molecular level. It offers insights into cell heterogeneity and enables the study of limited biological materials. Since its recognition as a valuable technique in 2011, single cell sequencing has yielded numerous ...read more
Big Data in Cancer Research
Cancer is a significant threat to human life and health, remaining a highly aggressive killer. It is a leading cause of death worldwide and represents a crucial medical issue for humanity. However, in the past decade, the effectiveness of new synthetic anticancer agents has not matched the current clinical speculation. ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Diabetic Cognitive Dysfunction: From Bench to Clinic
Current Medicinal Chemistry New Organ-Specific Drug Strategies Interfering in Signaling Pathways: Kinase Inhibitors and Other New Developmental Drugs in HCC
Current Signal Transduction Therapy Transforming Growth Factor-β Signaling in Motor Neuron Diseases
Current Molecular Medicine The Quest for Surrogate Markers of Angiogenesis: A Paradigm for Translational Research in Tumor Angiogenesis and Anti- Angiogenesis Trials
Current Molecular Medicine Update on Statins: Hope for Osteoporotic Fracture Healing Treatment
Current Drug Targets The Post Hoc Use of Randomised Controlled Trials to Explore Drug Associated Cancer Outcomes: Methodological Challenges
Current Drug Safety Inflammatory Bowel Disease and Celiac Disease: Overlaps in the Pathology and Genetics, and their Potential Drug Targets
Endocrine, Metabolic & Immune Disorders - Drug Targets Promising Anticancer Drug Candidates Based on the 7-methoxychromone Scaffold: Synthesis and Evaluation of Antiproliferative Activity
Letters in Drug Design & Discovery Application of Serial Analysis of Gene Expression in Cancer Research
Current Pharmaceutical Biotechnology Endoplasmic Stress Inhibitors for Homocysteine Induced Cardiovascular Disease
Current Pharmaceutical Design Synthesis of Pyrrole-Based Macrocycles as Molecular Probes for Multimodal Imaging Techniques: Recent Trends
Current Organic Synthesis Retinol-Binding Protein 4 and New Adipocytokines in Nonalcoholic Fatty Liver Disease
Current Pharmaceutical Design Endocannabinoid System: A Promising Therapeutic Target for the Treatment of Haematological Malignancies?
Current Medicinal Chemistry Genistein: A Boon for Mitigating Ischemic Stroke
Current Topics in Medicinal Chemistry <i>Cannabis Sativa</i> L. Flower and Bud Extracts Inhibited <i>In vitro</i> Cholinesterases and β-Secretase Enzymes Activities: Possible Mechanisms of Cannabis Use in Alzheimer Disease
Endocrine, Metabolic & Immune Disorders - Drug Targets The Complex Dynamics of Breast Cancer
Current Women`s Health Reviews Cancer Regulator MicroRNA: Potential Relevance in Diagnosis, Prognosis and Treatment of Cancer
Current Medicinal Chemistry Epigenetic Biomarkers for Risk Assessment of Particulate Matter Associated Lung Cancer
Current Drug Targets Recent Insights into the Development of Preclinical Trastuzumab- Resistant HER2+ Breast Cancer Models
Current Medicinal Chemistry HSV-1 Viral Oncolysis and Molecular Imaging with PET
Current Cancer Drug Targets