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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Qualitative and Quantitative Analyses of Resin-Bound Organic Compounds

Author(s): Mark Irving, Jason Cournoyer, Rongshi Li, Chris Santos and Bing Yan

Volume 4, Issue 4, 2001

Page: [353 - 362] Pages: 10

DOI: 10.2174/1386207013331066

Price: $65

Abstract

Methods for qualitative and quantitative analyses of resin-bound organic compounds are essential tools for chemistry development in solid-phase combinatorial and parallel syntheses. Here we discuss the use of gel-phase 19F NMR, the fluoride ion-selective electrode method, and spectrophotometry for monitoring solid-phase reactions. Our results indicate that the application of these diverse methods for analyzing the outcome of solid-phase combinatorial synthesis are sensitive and conclusive.

Keywords: Resin-Bound Organic Compounds, UV-Vis spectra, Gel-phase 19F NMR, Dansylhydrazine, Fourier Transform infrared, Hydroxybenzotriazole hydrate, Nuclear magnetic resonance, Tetrahydrofuran, Diisopropylethylamine, hexafluorophosphate


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