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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Dynamic Combinatorial Chemistry

Author(s): Ivan Huc and Regis Nguyen

Volume 4, Issue 1, 2001

Page: [53 - 74] Pages: 22

DOI: 10.2174/1386207013331273

Price: $65

Abstract

Dynamic combinatorial chemistry is based on the reversible combination of initial building blocks to form dynamic combinatorial libraries. It has recently emerged as an efficient strategy to detect and to evaluate affinity between the library products and a target molecule. In this review, examples from various fields of chemistry and biochemistry are presented and extensively discussed. The last section deals with the practical aspects for implementing this approach.

Keywords: Dynamic Combinatorial, potential diversity, dynamic generation, Si NMR, polycyclic oligomers, rational equilibiria, intramollecular forces, oligoamide 2


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