Abstract
In the last few years, significant advances in gene therapy have been made as a result of advances in many areas of molecular and cell biology, including the improvement of both viral and nonviral gene delivery systems, discovery of new therapeutic genes, better understanding of mechanism of disease progression, exploration of tissue specific promoter, receptor- and antibody-mediated targeting delivery, and development of better prodrug enzyme / prodrug systems. In this article, viral based gene therapy for prostate cancer will be reviewed and discussed. The areas of emphasis in this review are choice of viral vectors, comparison of delivery routes, development of prostate-targeted viruses, choice of therapeutic genes and strategies including corrective gene therapy (tumor suppressor gene and anti-oncogene gene approaches), suicide gene therapy, programmed cell death therapy, immunomodulation therapy, and conditional oncolytic virus approach. Among them, several examples will be discussed in detail for the scientific basis and therapeutic applications. In addition, prostate cancer gene therapy clinical trials, unresolved problems and future directions in this field will also be described.
Keywords: Viral Based Gene Therapy, Prostate Cancer, viral vectors, comparison, (tumor suppressor gene, PROSTATE - TARGETED VIRUSES, TRANSGENES, Corrective Gene Therapy, Tumor suppressor gene p16, MTS1 INK4A, CDKN2
Current Gene Therapy
Title: Viral Based Gene Therapy for Prostate Cancer
Volume: 1 Issue: 2
Author(s): Yi Lu
Affiliation:
Keywords: Viral Based Gene Therapy, Prostate Cancer, viral vectors, comparison, (tumor suppressor gene, PROSTATE - TARGETED VIRUSES, TRANSGENES, Corrective Gene Therapy, Tumor suppressor gene p16, MTS1 INK4A, CDKN2
Abstract: In the last few years, significant advances in gene therapy have been made as a result of advances in many areas of molecular and cell biology, including the improvement of both viral and nonviral gene delivery systems, discovery of new therapeutic genes, better understanding of mechanism of disease progression, exploration of tissue specific promoter, receptor- and antibody-mediated targeting delivery, and development of better prodrug enzyme / prodrug systems. In this article, viral based gene therapy for prostate cancer will be reviewed and discussed. The areas of emphasis in this review are choice of viral vectors, comparison of delivery routes, development of prostate-targeted viruses, choice of therapeutic genes and strategies including corrective gene therapy (tumor suppressor gene and anti-oncogene gene approaches), suicide gene therapy, programmed cell death therapy, immunomodulation therapy, and conditional oncolytic virus approach. Among them, several examples will be discussed in detail for the scientific basis and therapeutic applications. In addition, prostate cancer gene therapy clinical trials, unresolved problems and future directions in this field will also be described.
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Cite this article as:
Lu Yi, Viral Based Gene Therapy for Prostate Cancer, Current Gene Therapy 2001; 1 (2) . https://dx.doi.org/10.2174/1566523013348742
DOI https://dx.doi.org/10.2174/1566523013348742 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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Programmed Cell Death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes to the intricate landscape of cancer development and ...read more
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