Drug Metabolism Letters

Formation of a Toxic Quinoneimine Metabolite from Diclofenac: A Quantum Chemical Study open Access plus

Volume: 13   Issue: 1
Pp: 64-76
Muthusamy Ramesh* and Prasad V. Bharatam
DOI:10.2174/1872312812666180913120736

Comparison of Rat and Human Pulmonary Metabolism Using Precision-cut Lung Slices (PCLS) open Access plus

Volume: 13   Issue: 1
Pp: 53-63
Yildiz Yilmaz*, Gareth Williams, Markus Walles, Nenad Manevski, Stephan Krähenbühl and Gian Camenisch
DOI:10.2174/1872312812666181022114622

“Branched Tail” Oxyquinoline Inhibitors of HIF Prolyl Hydroxylase: Early Evaluation of Toxicity and Metabolism Using Liver-on-a-chip open Access plus

Volume: 13   Issue: 1
Pp: 45-52
Andrey A. Poloznikov*, Sergey V. Nikulin, Arpenik A. Zakhariants, Anna Y. Khristichenko, Dmitry M. Hushpulian, Ildar N. Gazizov, Vladimir I. Tishkov and Irina G. Gazaryan
DOI:10.2174/1872312813666181129100950

Unequal Absorption of Radiolabeled and Nonradiolabeled Drug from the Oral Dose Leads to Incorrect Estimates of Drug Absorption and Circulating Metabolites in a Mass Balance Study open Access plus

Volume: 13   Issue: 1
Pp: 37-44
Ryan H. Takahashi*, Jae H. Chang, Jodie Pang, Xiaorong Liang and Shuguang Ma
DOI:10.2174/1872312813666181129162237

Use of Cocktail Probe Drugs for Indexing Cytochrome P450 Enzymes in Clinical Pharmacology Studies – Review of Case Studies open Access plus

Volume: 13   Issue: 1
Pp: 3-18
Poonam Giri, Harilal Patel and Nuggehally R. Srinivas*
DOI:10.2174/1872312812666181119154734

Transport of Bupropion and its Metabolites by the Model CHO and HEK293 Cell Lines open Access plus

Volume: 13   Issue: 1
Pp: 25-36
Lyrialle W. Han, Chunying Gao, Yuchen Zhang, Joanne Wang and Qingcheng Mao*
DOI:10.2174/1872312813666181129101507

Effect of Aqueous Extract of Azadirachta indica Leaves on Pharmacokineics and Pharmacodynamics of Glipizide open Access plus

Volume: 13   Issue: 1
Pp: 19-24
Sugandha Chaudhari*, Shitalkumar Zambad and Mohammed Ali
DOI:10.2174/1872312812666181106115247

Imatinib Uptake into Cells is Not Mediated by Organic Cation Transporters OCT1, OCT2, or OCT3, But is Influenced by Extracellular pH open Access plus

Volume: 13  
Pp: 1-9
Jaurès Blanc Mettral, Nicolas Faller, Sandra Cruchon, Loïc Sottas, Thierry Buclin, Laurent Schild, Eva Choong, Aimable Nahimana and Laurent A. Decosterd*
DOI:10.2174/1872312813666190207150207

A Practical Perspective on the Evaluation of Small Molecule CNS Penetration in Drug Discovery open Access plus

Volume: 13  
Pp: 1-16
Liyue Huang*, Mary C. Wells and Zhiyang Zhao
DOI:10.2174/1872312813666190311125652

Prominence of Oxidative Stress in the Management of Anti-tuberculosis Drugs Related Hepatotoxicity open Access plus

Volume: 13  
Pp: 1-7
Preena John and Pravin Popatrao Kale*
DOI:10.2174/1872312813666190716155930

Using LC Retention Times in Organic Structure Determination: Drug Metabolite Identification open Access plus

Volume: 12   Issue: 2
Pp: 93-100
William L. Fitch*, Cyrus Khojasteh, Ignacio Aliagas and Kevin Johnson
DOI:10.2174/1872312812666180802093347

Quantitative Proteomics Reveals Changes in Transporter Protein Abundance in Liver, Kidney and Brain of Mice by Pregnancy open Access plus

Volume: 12   Issue: 2
Pp: 145-152
Michael Z. Liao, Chunying Gao, Deepak Kumar Bhatt, Bhagwat Prasad and Qingcheng Mao*
DOI:10.2174/1872312812666180625122810

Genistein Affects Expression of Cytochrome P450 (CYP450) Genes in Hepatocellular Carcinoma (HEPG2/C3A) Cell Line open Access plus

Volume: 12   Issue: 2
Pp: 138-144
Sandra R. Lepri, Daniele Sartori, Simone C. Semprebon*, Adrivanio Baranoski, Giuliana C. Coatti and Mario S. Mantovani
DOI:10.2174/1872312812666180709150440

A Novel In vitro Experimental System for the Evaluation of Enteric Drug Metabolism: Cofactor-Supplemented Permeabilized Cryopreserved Human Enterocytes (MetMax™ Cryopreserved Human Enterocytes) open Access plus

Volume: 12   Issue: 2
Pp: 132-137
Albert P. Li*, Kirsten Amaral and Ming-Chih D. Ho
DOI:10.2174/1872312812666180820142141

Hepatic Flavin-containing Monooxygenase and Aldehyde Oxidase Activities in Male Domestic Pigs at Different Ages open Access plus

Volume: 12   Issue: 2
Pp: 125-131
Steven X. Hu*
DOI:10.2174/1872312812666180913145334

In Vitro Drug-Drug Interaction Potential of Sulfoxide and/or Sulfone Metabolites of Albendazole, Triclabendazole , Aldicarb, Methiocarb, Montelukast and Ziprasidone open Access plus

Volume: 12   Issue: 2
Pp: 101-116
Poonam Giri, Lakshmikant Gupta, Sneha Naidu, Vipul Joshi, Nirmal Patel, Shyamkumar Giri and Nuggehally R. Srinivas*
DOI:10.2174/1872312812666180816164626

Cytochrome P450 3A4 Induction: Lumacaftor versus Ivacaftor Potentially Resulting in Significantly Reduced Plasma Concentration of Ivacaftor open Access plus

Volume: 12   Issue: 1
Pp: 71-74
Elena K. Schneider*
DOI:10.2174/1872312812666180328105259

In vitro Drug Metabolism Investigation of 7-Ethoxycoumarin in Human, Monkey, Dog and Rat Hepatocytes by High Resolution LC-MS/MS open Access plus

Volume: 12   Issue: 1
Pp: 33-53
Wan-Yong Feng*, Jenny Wen and Kathe Stauber
DOI:10.2174/1872312812666180418142056

Transactivation Assays that Identify Indirect and Direct Activators of Human Pregnane X Receptor (PXR, NR1I2) and Constitutive Androstane Receptor (CAR, NR1I3) open Access plus

Volume: 11   Issue: 2
Pp: 128-137
Marija Pinne*, Elsa Ponce and Judy L. Raucy
DOI:10.2174/1872312812666171207113639

The Metabolism of Methazolamide in Immortalized Human Keratinocytes, HaCaT Cells open Access plus

Volume: 10   Issue: 4
Pp: 295-305
Tetsuo Sasabe*, Shinichiro Maeda, Kenichi Kishida, Mariko Yamano, Yoshihiro Miwa and Toshihiro Sugiyama
DOI:10.2174/1872312811666170127160931

Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in Rat open Access plus

Volume: 10   Issue: 2
Pp: 91-100
Peter W. Fan, Jacob Z. Chen, M. Allan Jaochico, Hank La, Ning Liu, Teresa Mulder, Robert T. Cass, Matthew Durk, Kirsten Messick, Nicole Valle, Shannon Liu, Wendy Lee, James J. Crawford, Joachim Rudolf, Lesley J. Murray, S. Cyrus Khojasteh and Matthew Wright
DOI:10.2174/1872312810666160411144358

Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability open Access plus

Volume: 10   Issue: 2
Pp: 83-90
Samantha J. Richardson, April Bai, Ashutosh A. Kulkarni and Mehran F. Moghaddam
DOI:10.2174/1872312810666160223121836

Commentary: A Myriad Aberrations on Information of Ontogeny of Drug Metabolizing Enzymes in the Pediatric Population: An Obstacle for Personalizing Drug Therapy in the Pediatric Population open Access plus

Volume: 10   Issue: 2
Pp: 72-74
Chakradhara Rao S. Uppugunduri and Marc Ansari
DOI:10.2174/1872312810666160224143443

Formation of A Novel Purine Metabolite through CYP3A4 Bioactivation and Glutathione Conjugation open Access plus

Volume: 10   Issue: 2
Pp: 144-150
Julius L. Apuy, Cathie Xiang, Sarah Franc, Sayee G. Hegde, Robert Hubbard, Jingjing Zhao and Mehran F. Moghaddam
DOI:10.2174/1872312810666160511150558

Impact of Cytochrome P450 2C19*2 and *3 on Clopidogrel Loading Dose in Saudi Patients with Acute Coronary Syndrome open Access plus

Volume: 10   Issue: 1
Pp: 65-70
Hassan Khalaf, Ahmad AbdulRahman Al Meman and Seemab Rasool
DOI:10.2174/1872312810666151117122841

Influence of ABCB1 Gene Polymorphisms and P-Glycoprotein Activity on Cyclosporine Pharmacokinetics in Peripheral Blood Mononuclear Cells in Healthy Volunteers open Access plus

Volume: 2   Issue: 2
Pp: 76-82
Nicolas Ansermot, Michela Rebsamen, Jocelyne Chabert, Marc Fathi, Marianne Gex-Fabry, Youssef Daali, Marie Besson, Michel Rossier, Serge Rudaz, Denis Hochstrasser, Pierre Dayer and Jules Desmeules
DOI:10.2174/187231208784040951

Long Term Treatment with Tetradecylthioacetic Acid Improves the Antioxidant Status in Obese Zucker (fa/fa) Rats open Access plus

Volume: 2   Issue: 2
Pp: 138-145
Hege Wergedahl, Kjetil Berge, Pavol Bohov, Karl-Johan Tronstad, Lise Madsen and Rolf K. Berge
DOI:10.2174/187231208784041013