Drug Metabolism Letters


Zhiyang Zhao
Alliance Pharma
Malvern, PA


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P-Glycoprotein, but not Multidrug Resistance Protein 4, Plays a Role in the Systemic Clearance of Irinotecan and SN-38 in Mice

Volume:4   Issue: 4
Pp: 195-201
Michael Tagen, Yanli Zhuang, Fan Zhang, K. Elaine Harstead, Jun Shen, Paula Schaiquevich, Charles H. Fraga, John C. Panetta, Christopher M. Waters and Clinton F. Stewart
DOI: 10.2174/187231210792928251

P-Glycoprotein and Breast Cancer Resistance Protein Affect Disposition of Tandutinib, A Tyrosine Kinase Inhibitor

Volume:4   Issue: 4
Pp: 202-212
Johnny J. Yang, Mark N. Milton, Shaoxia Yu, Mingxiang Liao, Ning Liu, Jing-Tao Wu, Liang-Shang Gan, Suresh K. Balani, Frank W. Lee, Shimoga Prakash and Cindy Q. Xia
DOI: 10.2174/187231210792928279

Contribution of Three CYP3A Isoforms to Metabolism of R- and S-Warfarin

Volume:4   Issue: 4
Pp: 213-219
Drew R. Jones, So-Young Kim, Gunnar Boysen, Chul-Ho Yun and Grover P. Miller
DOI: 10.2174/187231210792928242

Reversible Covalent Binding of Neratinib to Human Serum Albumin In Vitro

Volume:4   Issue: 4
Pp: 220-227
Appavu Chandrasekaran, Li Shen, Susan Lockhead, Aram Oganesian, Jianyao Wang and JoAnn Scatina
DOI: 10.2174/187231210792928206

Daunorubicin Metabolism in Leukemic Cells Isolated from Patients with Acute Myeloid Leukemia

Volume:4   Issue: 4
Pp: 228-232
Alex Bogason, Michele Masquelier, Pierre Lafolie, Cristine Skogastierna, Christer Paul, Astrid Gruber and Sigurd Vitols
DOI: 10.2174/187231210792928260

In Vitro Screening of Metabolic Clearance Using Two Concentration Points

Volume:4   Issue: 4
Pp: 233-240
Eric T. Williams, Nadia Farah, Robert D. Pelletier and W. George Lai
DOI: 10.2174/187231210792928288

Comparative Efflux of Saquinavir, Ritonavir and Lopinavir from Primary Human Cells

Volume:4   Issue: 4
Pp: 241-245
Bilge Diker, Omar Janneh, Rolf P.G. van Heeswijk and Karen F.T. Copeland
DOI: 10.2174/187231210792928297

Co-Expression of Recombinant Human CYP2C9 with Human Cytochrome P450 Reductase in Protease Deficient S. cerevisiae Strain at a Higher Scale Yields an Enzyme of Higher Specific Activity

Volume:4   Issue: 4
Pp: 246-253
K. N. Purnachandra Rao, Sunil Kumar Suman, Y. Ravi Kiran, Arup Ranjan Kuanr, Anuj Kumar Gupta, Kunal Bhalla, Vipul Kumar, Prabuddha Kundu, Kajal Arora and Rajeev Soni
DOI: 10.2174/187231210792928233

Two Branched Polar Groups and Polar Linker Moieties of Thiophene Amide Derivatives Are Essential for MRP2/ABCC2 Recognition

Volume:4   Issue: 4
Pp: 254-261
Yiding Hu, Kathleen E. Sampson, Li Xing, Na Li, Bruce R. Heyde, Jin Xie and Yurong Lai
DOI: 10.2174/187231210792928215